{"id":"W2041249218","doi":"10.1021/bc100271v","title":"Design and Synthesis of Phospholipase C and A<sub>2</sub>-Activatable Near-Infrared Fluorescent Smart Probes","year":2010,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Molecular Sensors and Ion Detection","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; National Cancer Institute; University of Pennsylvania","keywords":"Chemistry; Fluorescence; Phospholipase A2; Fluorophore; Phospholipid; Moiety; Quenching (fluorescence); Phospholipase; In vivo; Biophysics; Stereochemistry; Enzyme; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000378793,0.0006320683,0.0005049622,0.0002641545,0.0001617392,0.0003731772,0.0006311761,0.0007106541,0.0008576682],"category_scores_gemma":[0.0002925216,0.0003963945,0.0003439796,0.0003518808,0.0003235404,0.000642237,0.0004401504,0.0008681291,0.0007752879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005769547,"about_ca_system_score_gemma":0.0004283532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002973458,"about_ca_topic_score_gemma":0.0004063084,"domain_scores_codex":[0.999774,0.00003118043,0.00002641891,0.00007085517,0.00006027795,0.00003722893],"domain_scores_gemma":[0.9998145,0.0000264857,0.00007315321,0.00001550782,0.00003508165,0.00003534356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006249785,0.0000199984,0.00006008027,0.00008355984,0.000006555889,0.00004402022,0.00001725446,0.0004841916,0.9940322,0.0006619707,0.00008625393,0.004441478],"study_design_scores_gemma":[0.00002028173,0.0002170026,0.0001747395,0.000004519118,0.00001033748,0.000130747,0.00000864637,0.001478752,0.9900781,0.0000882613,0.007777283,0.00001132893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7117236,0.01184508,0.262912,0.0008109822,0.0002916999,0.001238748,0.001090618,0.001047368,0.009039992],"genre_scores_gemma":[0.6350968,0.007912965,0.34105,0.0006500119,0.00009166891,0.001409375,0.001478443,0.0001537841,0.01215689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008576682,"threshold_uncertainty_score":0.004186153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006907924254113284,"score_gpt":0.190231297424411,"score_spread":0.1833233731702977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}