{"id":"W2041249840","doi":"10.1172/jci24311","title":"Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense; National Heart, Lung, and Blood Institute; American Heart Association","keywords":"Hairless; Notch signaling pathway; Biology; Cell biology; Vascular endothelial growth factor C; Endothelial stem cell; Lymphangiogenesis; Lymphatic Endothelium; Endothelium; Cancer research; Lymphatic system; Vascular endothelial growth factor B; Cell fate determination; Vascular endothelial growth factor A; Notch proteins; In vitro; Signal transduction; Immunology; Vascular endothelial growth factor; Endocrinology; Transcription factor; Genetics; Cancer; Gene; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002054758,0.000115044,0.00009824245,0.0001521107,0.00009030321,0.0002463787,0.0001149664,0.0001497713,0.001042303],"category_scores_gemma":[0.000152044,0.00008983212,0.000116937,0.00009245145,0.0001277959,0.00008149912,0.0001035698,0.0002042471,0.0001685826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003450143,"about_ca_system_score_gemma":0.0001291604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006620873,"about_ca_topic_score_gemma":0.000737535,"domain_scores_codex":[0.9998263,0.00004956876,0.00001660385,0.00002890538,0.00004421723,0.00003449357],"domain_scores_gemma":[0.9999462,0.00001486134,0.00001495311,0.00000889392,0.000004651616,0.0000104818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468842,0.00002275649,0.0002530161,0.00001366787,0.000003886169,0.00004067758,0.000017058,0.00008019434,0.9977665,0.0002273856,0.00004154476,0.001386415],"study_design_scores_gemma":[0.00002968409,0.0002813886,0.003501706,0.000005976298,0.00002233589,0.0004544525,0.00002396925,0.001028779,0.9905906,0.00009269305,0.003963843,0.000004586222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971082,0.0008029929,0.0007831564,0.00003453233,0.000009389997,0.000008852148,0.0001714965,0.00002179591,0.001059619],"genre_scores_gemma":[0.9975321,0.0003969183,0.0007771807,0.00002901395,0.000002864481,0.00001288228,0.0002109669,0.000007191215,0.001030773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042303,"threshold_uncertainty_score":0.003486872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03533613215272959,"score_gpt":0.3592779934407073,"score_spread":0.3239418612879777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}