{"id":"W2041304599","doi":"10.1074/jbc.m114.618827","title":"Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+ Release Activation and Termination","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Ryanodine receptor; Ryanodine receptor 2; Gating; Caffeine; Biophysics; Cell biology; Chemistry; Terminal (telecommunication); Receptor; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000221481,0.0003203086,0.0003138342,0.00009507233,0.0001559623,0.000314135,0.0002851458,0.0004690625,0.0004222389],"category_scores_gemma":[0.0002048701,0.0001502013,0.000310179,0.00009486486,0.0003666373,0.0003776156,0.0002715566,0.0004767421,0.0003000474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002145186,"about_ca_system_score_gemma":0.0001876816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004114849,"about_ca_topic_score_gemma":0.000387618,"domain_scores_codex":[0.9998527,0.00002339754,0.00002605129,0.00003963023,0.00003278263,0.00002543922],"domain_scores_gemma":[0.9997762,0.00005410057,0.00007663341,0.00002219984,0.00002072798,0.00005018921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021246,0.00000988223,0.0002669329,0.00002617618,0.000002349838,0.00006509087,0.00001130583,0.00007699927,0.9989614,0.00006689851,0.000006892924,0.0004038174],"study_design_scores_gemma":[0.00004942427,0.0002446932,0.02843908,0.00001923395,0.00003216025,0.001093338,0.00007141633,0.002383982,0.9651156,0.0002078081,0.002324874,0.00001830274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994127,0.002288266,0.002604553,0.00006605509,0.00001144689,0.00001890014,0.00014587,0.00001859697,0.0007190629],"genre_scores_gemma":[0.9959974,0.000639627,0.002379015,0.00007930648,0.000007515611,0.00002938731,0.0002452083,0.00001030675,0.0006123087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004690625,"threshold_uncertainty_score":0.001556456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509194834884607,"score_gpt":0.2587954398210979,"score_spread":0.2437034914722518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}