{"id":"W2041325459","doi":"10.1111/jdv.12555","title":"A Randomized, blinded assessor study to Evaluate the efFIcacy and safety of etanercept 50 mg once weekly plus as Needed topical agent vs. Etanercept 50 mg twice weekly in patients with moderate to severe plaque psoriasis (<scp>REFINE</scp>)","year":2014,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Merck Canada Inc. (Canada); Lynde Centre for Dermatology; Moncton Hospital; Amgen (Canada); Centre de Recherche Dermatologique du Québec Métropolitain; Innovaderm (Canada); Probity Medical Research","funders":"Astellas Pharma; Pfizer; Eli Lilly and Company; Incyte; Amgen","keywords":"Etanercept; Medicine; Clinical endpoint; Randomized controlled trial; Psoriasis Area and Severity Index; Psoriasis; Internal medicine; Body surface area; Confidence interval; Surgery; Gastroenterology; Dermatology; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01273268,0.002678008,0.006417559,0.0007004577,0.001069552,0.001675405,0.001850258,0.003048174,0.01271835],"category_scores_gemma":[0.00972876,0.001496369,0.002195821,0.0006681466,0.00236913,0.001954619,0.000852271,0.003541923,0.002152042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001190896,"about_ca_system_score_gemma":0.003055527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006740321,"about_ca_topic_score_gemma":0.001381126,"domain_scores_codex":[0.9930726,0.004583474,0.0004508029,0.0009292996,0.0004862133,0.0004777228],"domain_scores_gemma":[0.9911702,0.003439661,0.002266361,0.001073176,0.0006686095,0.001381991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884918,0.006647741,0.0002201434,0.0001357229,0.0003427904,0.000009351618,0.00002497925,0.00008511438,0.0008338064,0.00005260464,0.0002476586,0.002908302],"study_design_scores_gemma":[0.9631723,0.0356857,0.0004100934,0.000009654872,0.00016036,0.000009773974,0.000005730807,0.0001865711,0.000114481,0.00007645099,0.0001626886,0.000006239864],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951627,0.002704649,0.004031682,0.0008632189,0.001807067,0.0326434,0.002874814,0.0003173345,0.003130946],"genre_scores_gemma":[0.9215603,0.001359119,0.01160541,0.002321687,0.001850856,0.05457889,0.001479724,0.00007563476,0.005168284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01273268,"threshold_uncertainty_score":0.06733769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206092658047634,"score_gpt":0.2690851477479169,"score_spread":0.2484758819431535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}