{"id":"W2041337283","doi":"10.1021/jm2015099","title":"From the First Selective Non-Peptide AT<sub>2</sub>Receptor Agonist to Structurally Related Antagonists","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Agonist; Chemistry; Receptor; Antagonist; Stereochemistry; Chemical synthesis; Competitive antagonist; Structure–activity relationship; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009629515,0.0004029603,0.0003445804,0.0002065566,0.0001276562,0.0003044742,0.0003230383,0.0002414491,0.003561226],"category_scores_gemma":[0.0001238227,0.000184197,0.0002320074,0.0001672748,0.0001997059,0.0002641502,0.000265116,0.0007183487,0.001877311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112463,"about_ca_system_score_gemma":0.0002595786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002403152,"about_ca_topic_score_gemma":0.0006655688,"domain_scores_codex":[0.9999212,0.00001223457,0.00001002068,0.00001830599,0.00001789408,0.00002033354],"domain_scores_gemma":[0.9999621,0.000005197982,0.000008791641,0.000005361291,0.000006238156,0.00001233145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003756643,0.0001034708,0.0003065077,0.0003999837,0.00002288304,0.0005125213,0.00008386376,0.0006261486,0.9589444,0.001877659,0.0008885161,0.03585846],"study_design_scores_gemma":[0.0003113562,0.008047249,0.006116101,0.0001009319,0.0001476637,0.004151873,0.0000638545,0.0009191758,0.7957143,0.001233167,0.1831333,0.00006111195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8838693,0.04431365,0.02138798,0.001138527,0.0004332254,0.001172104,0.002184387,0.000572541,0.04492825],"genre_scores_gemma":[0.9089577,0.0329225,0.02928752,0.001863388,0.0002538306,0.0004347611,0.002794455,0.0001081097,0.02337762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003561226,"threshold_uncertainty_score":0.01191348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004845431412579254,"score_gpt":0.2214941753796101,"score_spread":0.2166487439670308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}