{"id":"W2041337283","doi":"10.1021/jm2015099","title":"From the First Selective Non-Peptide AT<sub>2</sub>Receptor Agonist to Structurally Related Antagonists","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Agonist; Chemistry; Receptor; Antagonist; Stereochemistry; Chemical synthesis; Competitive antagonist; Structure–activity relationship; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005515042,0.0002643212,0.0003212355,0.0000209254,0.0002411735,0.00003267643,0.0004359704,0.0002459531,0.0002547648],"category_scores_gemma":[0.0002501059,0.0001816906,0.0002184041,0.0001300827,0.00009310208,0.00001361612,0.0001396835,0.000445686,0.00002299024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399127,"about_ca_system_score_gemma":0.0001547158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001653506,"about_ca_topic_score_gemma":0.000006479392,"domain_scores_codex":[0.9982716,0.00004151887,0.0005562959,0.0002403238,0.0004675029,0.000422776],"domain_scores_gemma":[0.9985672,0.00006237601,0.0004631168,0.0002752571,0.000240119,0.0003919353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003183493,0.00003659814,0.001585344,0.00001755866,0.0001891597,0.00001064878,0.0005575328,0.00003120131,0.9672497,0.000001260377,0.02925215,0.0007505215],"study_design_scores_gemma":[0.0007305068,0.0002271322,0.001803601,0.0001208767,0.00008546051,0.0003567977,0.0004964829,0.000006952896,0.9697402,0.00003338046,0.0261806,0.0002180654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960248,0.001256599,0.0003059949,0.001095539,0.0007710342,0.0001089419,0.00002898814,0.000006104834,0.0004019266],"genre_scores_gemma":[0.9946254,0.0001587806,0.0005302242,0.0006067067,0.003784845,0.000004752058,0.00006178764,0.00003544497,0.0001920897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003071547,"threshold_uncertainty_score":0.7409126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004845431412579254,"score_gpt":0.2214941753796101,"score_spread":0.2166487439670308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}