{"id":"W2041346792","doi":"10.1002/bit.20947","title":"Retroviral vector production using suspension‐adapted 293GPG cells in a 3L acoustic filter‐based perfusion bioreactor","year":2006,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; National Research Council Canada; Biotechnology Research Institute","funders":"","keywords":"Retrovirus; Cell culture; Viral vector; Vesicular stomatitis virus; Bioreactor; Biology; Transfection; Virology; Titer; Virus; Murine leukemia virus; Molecular biology; Recombinant DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017793,0.0002063089,0.0001713137,0.0003166913,0.00007743246,0.00001675981,0.0001341903,0.0004913163,0.000009618518],"category_scores_gemma":[0.00004374361,0.0002007732,0.00004344768,0.0003232548,0.0001322497,0.00000683434,0.00009118495,0.0002479313,0.000002946298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005042569,"about_ca_system_score_gemma":0.0000514522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007202883,"about_ca_topic_score_gemma":0.0002913721,"domain_scores_codex":[0.9988109,0.00003501045,0.0002042673,0.0004665365,0.0001073491,0.0003759554],"domain_scores_gemma":[0.9995427,0.000009132434,0.00004775113,0.0003223662,0.00003723242,0.00004087386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003525967,0.00005578918,0.0004516376,0.00002522947,0.000009440937,0.00001370597,0.000004073015,0.004248562,0.9941064,0.00000881484,0.00004380118,0.0006799399],"study_design_scores_gemma":[0.0005059279,0.000739203,0.0009715678,0.00003630881,0.00001063708,0.000020462,0.00001866537,0.01684706,0.9801965,0.000005594001,0.0004198896,0.0002282306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996896,0.0007554544,0.001466387,0.0003418227,0.0001894108,0.0002547272,0.00001229819,0.00007781986,0.000006110283],"genre_scores_gemma":[0.9982836,0.0001122583,0.001270658,0.00002468211,0.0001703986,0.00001064461,0.00005060084,0.00003158325,0.00004562063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01390996,"threshold_uncertainty_score":0.8187294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209093925035836,"score_gpt":0.2353116813313803,"score_spread":0.2232207420810219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}