{"id":"W2041352944","doi":"10.1016/j.cellimm.2009.10.007","title":"Role of TLR2- and TLR4-mediated signaling in Mycobacterium tuberculosis-induced macrophage death","year":2009,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"TLR4; TLR2; Apoptosis; Biology; Macrophage; p38 mitogen-activated protein kinases; Necrosis; Signal transduction; Programmed cell death; Toll-like receptor; Mycobacterium tuberculosis; Tuberculosis; MAPK/ERK pathway; Tumor necrosis factor alpha; Cell biology; Microbiology; Immunology; Innate immune system; Immune system; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003441517,0.0002241903,0.000456631,0.0003288688,0.00008525568,0.00001005104,0.0001927365,0.0005284793,0.0002269363],"category_scores_gemma":[0.0001081288,0.0002218263,0.00007890702,0.0002035569,0.0001237483,0.0001271539,0.00006991917,0.000404503,0.0001497986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004465604,"about_ca_system_score_gemma":0.000053256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001304738,"about_ca_topic_score_gemma":0.000005021162,"domain_scores_codex":[0.998245,0.0004257922,0.000555139,0.000298298,0.00003194516,0.0004438385],"domain_scores_gemma":[0.9992826,0.0001437458,0.0001811492,0.0003213074,0.00005484465,0.00001637929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004384552,0.0001073688,0.0008725626,0.00001169666,0.00009336089,0.0000156575,0.000696348,0.00000245772,0.9912368,0.001010472,0.000005874494,0.005508923],"study_design_scores_gemma":[0.001485753,0.000438322,0.05801402,0.00004452891,0.00002968378,0.00006059243,0.0002822676,0.00002415883,0.9376628,0.000359059,0.001402187,0.0001966448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809318,0.01782001,0.00002861261,0.0001841631,0.0002284162,0.0002315722,0.000004884799,0.00004819479,0.0005223381],"genre_scores_gemma":[0.9990798,0.0004377377,0.00004648613,0.00006693872,0.00001524356,0.00001000657,0.0001673026,0.00001561045,0.0001608254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05714146,"threshold_uncertainty_score":0.9045814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006176385280084932,"score_gpt":0.2034481961663571,"score_spread":0.1972718108862722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}