{"id":"W2041352944","doi":"10.1016/j.cellimm.2009.10.007","title":"Role of TLR2- and TLR4-mediated signaling in Mycobacterium tuberculosis-induced macrophage death","year":2009,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"TLR4; TLR2; Apoptosis; Biology; Macrophage; p38 mitogen-activated protein kinases; Necrosis; Signal transduction; Programmed cell death; Toll-like receptor; Mycobacterium tuberculosis; Tuberculosis; MAPK/ERK pathway; Tumor necrosis factor alpha; Cell biology; Microbiology; Immunology; Innate immune system; Immune system; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000781209,0.000644828,0.0004198593,0.0005193658,0.0005849347,0.0007543137,0.0003414993,0.001049334,0.003172125],"category_scores_gemma":[0.0003457214,0.0002485458,0.0004753185,0.0001982728,0.0004287664,0.0007453351,0.0005925114,0.0009339609,0.0008014208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006614714,"about_ca_system_score_gemma":0.0003863845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002863865,"about_ca_topic_score_gemma":0.0002753424,"domain_scores_codex":[0.9994513,0.0001884072,0.0000458943,0.00003598432,0.00008086295,0.0001975453],"domain_scores_gemma":[0.99976,0.00005074636,0.00005672082,0.00003653015,0.00004881454,0.00004713343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005007181,0.0002218825,0.002131307,0.0003328492,0.00004864425,0.0007067879,0.00007612851,0.0004397855,0.9757587,0.001453209,0.0004064594,0.0134171],"study_design_scores_gemma":[0.000343398,0.00142601,0.03239985,0.00008945131,0.00009597712,0.00282725,0.000352735,0.004121175,0.9475048,0.002288242,0.008518625,0.00003245005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659326,0.01842815,0.00521031,0.001028624,0.000194262,0.00009230802,0.0006423722,0.0001325523,0.00833891],"genre_scores_gemma":[0.9909977,0.002024194,0.001980687,0.0001613612,0.00006307141,0.00008564892,0.0003241244,0.00001028508,0.004352921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003172125,"threshold_uncertainty_score":0.01061183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006176385280084932,"score_gpt":0.2034481961663571,"score_spread":0.1972718108862722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}