{"id":"W2041368434","doi":"10.1074/jbc.m209933200","title":"Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient Mice","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Renin–angiotensin system; Internal medicine; Angiotensin II; Endocrinology; Medicine; Kidney; Hydronephrosis; Genetically modified mouse; Transgene; Biology; Urinary system; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834225,0.0004962679,0.0004697075,0.0005517401,0.0001692845,0.0004064952,0.0003772452,0.0003589407,0.001075],"category_scores_gemma":[0.0002285786,0.0001803845,0.0002910524,0.000143399,0.0004953975,0.000279522,0.0002359076,0.001260241,0.0003307273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002243607,"about_ca_system_score_gemma":0.0003710998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005986568,"about_ca_topic_score_gemma":0.001160791,"domain_scores_codex":[0.9998333,0.00002005933,0.000018246,0.00004147441,0.00004609822,0.00004073787],"domain_scores_gemma":[0.9997237,0.00003255423,0.00009172045,0.00002689745,0.00003297817,0.00009201421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008781184,0.00004193943,0.00008543063,0.00002684405,0.000008978314,0.0001021791,0.00001226647,0.00004624888,0.9981066,0.0001223069,0.00003236862,0.001327094],"study_design_scores_gemma":[0.00004913609,0.0004649461,0.00162127,0.000009012047,0.00004669812,0.0006330701,0.00003208899,0.0005463446,0.9951034,0.0001072304,0.001380735,0.000006078301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896027,0.0008636992,0.007389277,0.000161478,0.00006265056,0.00004154675,0.0002868129,0.0003848815,0.001206944],"genre_scores_gemma":[0.9860572,0.001528786,0.007955024,0.0001050983,0.00003857421,0.00006070965,0.0004528432,0.0001310032,0.003670819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075,"threshold_uncertainty_score":0.003596246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03623296257676963,"score_gpt":0.2650257374035929,"score_spread":0.2287927748268232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}