{"id":"W2041389921","doi":"10.1371/journal.ppat.1000514","title":"NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Infection","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Mishima Kaiun Memorial Foundation; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Ministry of Education, Culture, Sports, Science and Technology; Kowa Life Science Foundation; Kowa Company; Naito Foundation","keywords":"Trypanosoma cruzi; Innate immune system; TRIF; Biology; Toll-like receptor; Immune system; Intracellular parasite; Immunology; Microbiology; Cell biology; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190388,0.0004228832,0.0002498692,0.0002111279,0.0002829698,0.0003266145,0.0002430729,0.00034105,0.001155651],"category_scores_gemma":[0.0001866149,0.0001627012,0.0002428271,0.0001466778,0.0003289939,0.0003688292,0.0002237406,0.0006268668,0.0004227089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472587,"about_ca_system_score_gemma":0.0003300561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000721295,"about_ca_topic_score_gemma":0.0009133862,"domain_scores_codex":[0.9998149,0.00002578027,0.00001899985,0.00004016311,0.00004579852,0.00005446328],"domain_scores_gemma":[0.9997848,0.00002565591,0.00007538763,0.00001856909,0.00003254076,0.00006305105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002184332,0.00002499347,0.0005203352,0.0000895562,0.000003496416,0.0001017827,0.00006028825,0.00002648205,0.99795,0.00008842855,0.00005923442,0.0008569252],"study_design_scores_gemma":[0.0001166313,0.0004155225,0.0424902,0.00006754087,0.00006213285,0.002395398,0.0002302636,0.001793036,0.9442795,0.0003642832,0.007765849,0.00001957261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859306,0.00854328,0.002609853,0.0002599665,0.00008917975,0.00003983899,0.0005568836,0.0001396596,0.001830648],"genre_scores_gemma":[0.9930461,0.002350735,0.001506082,0.00007094617,0.00004892017,0.0000602911,0.0008028765,0.00001880546,0.002095268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155651,"threshold_uncertainty_score":0.003866017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536606913120287,"score_gpt":0.288940109455977,"score_spread":0.2635740403247742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}