{"id":"W2041427716","doi":"10.1159/000126505","title":"Downregulation of Protein Kinase C Levels Leads to Inhibition of GnRH-Stimulated Gonadotropin Secretion from Dispersed Pituitary Cells of Goldfish","year":2008,"lang":"en","type":"article","venue":"Neuroendocrinology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Medical Research Council; Alberta Heritage Foundation for Medical Research","keywords":"Internal medicine; Endocrinology; Downregulation and upregulation; Secretion; Gonadotropin; Gonadotropin-releasing hormone; Protein kinase A; Pituitary gland; Chemistry; Biology; Hormone; Kinase; Medicine; Luteinizing hormone; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038336,0.0004080381,0.0004476951,0.000163699,0.0001915091,0.0003574561,0.000245948,0.0002081241,0.001149088],"category_scores_gemma":[0.0001405318,0.0002394575,0.0003476882,0.0001367517,0.0003478936,0.0001963496,0.0003241829,0.0006555482,0.0004042953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007589622,"about_ca_system_score_gemma":0.0005209258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00371922,"about_ca_topic_score_gemma":0.004911855,"domain_scores_codex":[0.9998847,0.000006005953,0.00001572621,0.00003739176,0.00002442169,0.00003171092],"domain_scores_gemma":[0.9999095,0.0000127603,0.00001779112,0.00001708067,0.0000112925,0.00003155995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009579809,0.000005507302,0.0001367119,0.00003324957,0.000003398206,0.00004136583,0.00001213933,0.00001761774,0.9993913,0.00001671165,0.00001493126,0.0002311482],"study_design_scores_gemma":[0.00007082637,0.0003246906,0.01491461,0.00001094363,0.0000316458,0.0002284359,0.0001115916,0.0006578117,0.9810621,0.00003547144,0.00254284,0.000008852743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972898,0.0009769431,0.0006578393,0.00009093997,0.00003603864,0.0000278615,0.0002893044,0.00004034821,0.0005909813],"genre_scores_gemma":[0.989719,0.001779478,0.001949019,0.00009505315,0.00001520714,0.00009019763,0.001065777,0.00002880103,0.005257295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00371922,"threshold_uncertainty_score":0.007395148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149766177668703,"score_gpt":0.2437035440495854,"score_spread":0.2222058822728984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}