{"id":"W2041435794","doi":"10.1089/jir.2010.0083","title":"Interleukin-23-Induced Interleukin-23 Receptor Subunit Expression Is Mediated by the Janus Kinase/Signal Transducer and Activation of Transcription Pathway in Human CD4 T Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; STAT4; Janus kinase; STAT1; Signal transduction; IL-2 receptor; Biology; ZAP70; Common gamma chain; STAT3; T cell; STAT protein; JAK-STAT signaling pathway; Molecular biology; Receptor; stat; Interleukin-21 receptor; Immune system; Immunology; Tyrosine kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001253061,0.0002686792,0.0002421384,0.000268458,0.0001877591,0.0003503978,0.0001475586,0.0001984909,0.00254926],"category_scores_gemma":[0.000113714,0.0001722577,0.0003261135,0.0002752453,0.0001405435,0.000120567,0.0001661523,0.0005233194,0.0009917879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003180681,"about_ca_system_score_gemma":0.0002465373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059107,"about_ca_topic_score_gemma":0.0007191035,"domain_scores_codex":[0.9997421,0.00004830159,0.00002411718,0.00005023213,0.00006300664,0.00007225229],"domain_scores_gemma":[0.9999611,0.000006217902,0.000007441017,0.000006225236,0.000007158106,0.00001184058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002659769,0.00003750011,0.0003128118,0.0000748193,0.000009858283,0.0001458686,0.00003297889,0.00009097398,0.9959858,0.00008196005,0.000146555,0.002814843],"study_design_scores_gemma":[0.000174506,0.000849383,0.02026151,0.00002902208,0.0000694615,0.001547295,0.0001303798,0.002297818,0.9567497,0.0002304903,0.0176411,0.00001946069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737504,0.0110619,0.006772181,0.0003816035,0.0001958371,0.0001592505,0.001844326,0.0001859499,0.005648596],"genre_scores_gemma":[0.9868685,0.003672354,0.002482847,0.0001342967,0.00005310875,0.0001588967,0.002081682,0.00001974158,0.004528633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254926,"threshold_uncertainty_score":0.008528113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04505741519750242,"score_gpt":0.3058214354732876,"score_spread":0.2607640202757852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}