{"id":"W2041435794","doi":"10.1089/jir.2010.0083","title":"Interleukin-23-Induced Interleukin-23 Receptor Subunit Expression Is Mediated by the Janus Kinase/Signal Transducer and Activation of Transcription Pathway in Human CD4 T Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; STAT4; Janus kinase; STAT1; Signal transduction; IL-2 receptor; Biology; ZAP70; Common gamma chain; STAT3; T cell; STAT protein; JAK-STAT signaling pathway; Molecular biology; Receptor; stat; Interleukin-21 receptor; Immune system; Immunology; Tyrosine kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002128129,0.0002808319,0.0005224361,0.000728053,0.0001903067,0.00004752201,0.0005523649,0.0004458338,0.0009991078],"category_scores_gemma":[0.00009644052,0.0001873197,0.0001932903,0.0003703151,0.0003155526,0.000331021,0.0000728666,0.001731545,0.00003632324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000144973,"about_ca_system_score_gemma":0.0001236025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001788203,"about_ca_topic_score_gemma":0.0001510764,"domain_scores_codex":[0.9968792,0.001106619,0.0009469757,0.0003145701,0.0002808153,0.0004717978],"domain_scores_gemma":[0.9981967,0.0005423808,0.000394145,0.0002939961,0.0004946034,0.00007821334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002923786,0.0004770876,0.0004548578,0.00004234166,0.0001619374,0.000009625262,0.004006483,4.975496e-7,0.9745736,0.00001514048,0.002866053,0.01446865],"study_design_scores_gemma":[0.003364116,0.002385125,0.001292878,0.0004293692,0.00003143191,0.00005943968,0.001448316,0.000004340771,0.9866706,0.00004403959,0.004113137,0.0001571945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975299,0.0004832369,0.0000632884,0.0007569143,0.0005486194,0.0003655746,0.00009181698,0.00001056402,0.0001501097],"genre_scores_gemma":[0.9989126,0.000197095,0.00002630272,0.00003339881,0.0001181144,0.00002360447,0.0000990569,0.00003301104,0.000556856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01431145,"threshold_uncertainty_score":0.9999141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04505741519750242,"score_gpt":0.3058214354732876,"score_spread":0.2607640202757852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}