{"id":"W2041438017","doi":"10.1039/c4md00317a","title":"Structure–activity relationship studies of SETD8 inhibitors","year":2014,"lang":"en","type":"article","venue":"MedChemComm","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium; Toronto Public Health","funders":"National Institute of General Medical Sciences; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Eli Lilly Canada; Wellcome Trust; Novartis Foundation","keywords":"Substrate (aquarium); Computational biology; Chemistry; Stereochemistry; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003801271,0.0005450252,0.0006054135,0.0003655168,0.0001937661,0.0003728367,0.0005856318,0.0002897313,0.003138013],"category_scores_gemma":[0.0004026169,0.0002308842,0.0003818785,0.0005142049,0.0001939814,0.0002789425,0.0001979706,0.0008640811,0.000519571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009474128,"about_ca_system_score_gemma":0.0002890007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096087,"about_ca_topic_score_gemma":0.002240335,"domain_scores_codex":[0.9997932,0.00004214465,0.00001926919,0.00003479868,0.00006313029,0.00004734376],"domain_scores_gemma":[0.9998631,0.00003464389,0.00002426779,0.00001093623,0.00003648552,0.000030492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003745135,0.001567346,0.003175998,0.0006590877,0.0002745277,0.0005772873,0.0001261425,0.0181402,0.9234555,0.001341116,0.003162699,0.04377487],"study_design_scores_gemma":[0.001000143,0.01550048,0.00859414,0.00004576291,0.0003592371,0.001698498,0.00008997216,0.02271617,0.9206892,0.0006225189,0.02858673,0.00009715227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604843,0.02329409,0.004570317,0.0004573179,0.0001138621,0.000153686,0.002570259,0.0001690754,0.008187128],"genre_scores_gemma":[0.9829069,0.008315963,0.002044455,0.0001377892,0.00002829292,0.00005679412,0.003345885,0.00001625961,0.003147682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003138013,"threshold_uncertainty_score":0.01049769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03170171521642241,"score_gpt":0.290799962475859,"score_spread":0.2590982472594366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}