{"id":"W2041438017","doi":"10.1039/c4md00317a","title":"Structure–activity relationship studies of SETD8 inhibitors","year":2014,"lang":"en","type":"article","venue":"MedChemComm","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium; Toronto Public Health","funders":"National Institute of General Medical Sciences; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Eli Lilly Canada; Wellcome Trust; Novartis Foundation","keywords":"Substrate (aquarium); Computational biology; Chemistry; Stereochemistry; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002602425,0.0001078607,0.0001516537,0.00002817682,0.00006491529,0.000004940789,0.0001122128,0.0001098609,0.00001619066],"category_scores_gemma":[0.000553639,0.00009506047,0.00006192154,0.000067405,0.0001060557,0.000002701835,0.00009592524,0.00009643016,0.000004791941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000804502,"about_ca_system_score_gemma":0.00002095583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005117273,"about_ca_topic_score_gemma":0.00001960309,"domain_scores_codex":[0.9993263,0.0001121775,0.000142382,0.00018066,0.0001061878,0.000132242],"domain_scores_gemma":[0.9994235,0.00005818744,0.00009492919,0.0003060439,0.00007307211,0.00004427183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003255075,0.00002859828,0.02330274,0.00006960455,0.00004797037,2.380663e-7,0.0001916634,0.00001171327,0.9698409,0.0007004928,0.001620383,0.004153166],"study_design_scores_gemma":[0.0002380319,0.00012429,0.006025591,0.00001551187,0.00001176875,0.000003103133,0.00006022139,0.00001597864,0.9835255,0.001548022,0.008322035,0.0001100042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964806,0.0004675773,0.0003150219,0.0001571905,0.0001496887,0.00009794426,0.00001693177,0.00001203187,0.00230303],"genre_scores_gemma":[0.9986398,0.00001687085,0.000718571,0.00008226905,0.0002202624,0.000008811093,0.000028253,0.00001251695,0.0002726812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01727715,"threshold_uncertainty_score":0.3876453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03170171521642241,"score_gpt":0.290799962475859,"score_spread":0.2590982472594366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}