{"id":"W2041470845","doi":"10.4331/wjbc.v2.i3.39","title":"Allosteric inhibitors of plasma membrane Ca<sup>2+</sup>pumps: Invention and applications of caloxins","year":2011,"lang":"en","type":"article","venue":"World Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Heart and Stroke Foundation of Canada","keywords":"Allosteric regulation; Gene isoform; Disease; Neuroscience; Bioinformatics; Biology; Medicine; Cell biology; Pharmacology; Computational biology; Biochemistry; Gene; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001959492,0.0001061513,0.0002035886,0.00004989223,0.00002828522,0.00000346572,0.0001102868,0.0001572144,0.0001353674],"category_scores_gemma":[0.00005864988,0.00008205911,0.0001267674,0.0001321946,0.0001764601,0.000005721613,0.00005462468,0.0001059759,8.217701e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009750338,"about_ca_system_score_gemma":0.00002908317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004946059,"about_ca_topic_score_gemma":0.000001049396,"domain_scores_codex":[0.9991502,0.00003306305,0.0004723535,0.0001404246,0.0001038362,0.0001001031],"domain_scores_gemma":[0.9992035,0.00001528153,0.00040206,0.0001187954,0.0001747836,0.00008557922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005509,0.0001731166,0.002750287,0.00008331813,0.00006347033,0.000001400184,0.00007280522,0.0001481358,0.9940501,0.00002866272,0.0003369823,0.001991136],"study_design_scores_gemma":[0.000619815,0.0002634532,0.0007749283,0.0000415481,0.00002907406,0.00006731747,0.0002501655,0.000165032,0.9886503,0.0002307016,0.008796549,0.0001111195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965003,0.0003532579,0.0005934802,0.00004200178,0.00005095913,0.00007538003,0.0000141993,0.000003272626,0.002367131],"genre_scores_gemma":[0.9985655,0.0002421055,0.0004166522,0.00003134577,0.0002894528,0.000004735803,0.00004082444,0.00000607401,0.0004033054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008459567,"threshold_uncertainty_score":0.3346273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384063870781005,"score_gpt":0.2324217597370252,"score_spread":0.2085811210292151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}