{"id":"W2041478559","doi":"10.1074/jbc.m706884200","title":"Secretory Leucocyte Protease Inhibitor Inhibits Interferon-γ-induced Cathepsin S Expression","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Science Foundation Ireland; Health Research Board","keywords":"Cathepsin S; Protease; Protease inhibitor (pharmacology); Interferon; Chemistry; Cathepsin; Cell biology; Biology; Virology; Enzyme; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000811616,0.0001875421,0.0003228742,0.0000579632,0.0001002055,0.00001096916,0.0002767346,0.0006433136,0.0004592145],"category_scores_gemma":[0.0005442224,0.0001260452,0.0002398354,0.0001022756,0.0001211113,0.0001198414,0.0001317721,0.0007430695,0.00005164364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001364273,"about_ca_system_score_gemma":0.0001191644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001887383,"about_ca_topic_score_gemma":1.854307e-7,"domain_scores_codex":[0.9985757,0.0001359716,0.0007306862,0.000174993,0.00006953544,0.0003131052],"domain_scores_gemma":[0.9988809,0.0001016201,0.0006008301,0.0001875734,0.0001685077,0.00006057083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001690325,0.0001313373,0.0007614538,0.00002445429,0.00003074835,0.00002385849,0.0000994224,4.143471e-7,0.9943279,0.000002532115,0.0005537564,0.002353771],"study_design_scores_gemma":[0.001137098,0.0003113125,0.002626589,0.0002471413,0.00001163975,0.0004015427,0.000155885,2.443516e-7,0.9882113,0.0000379638,0.006702248,0.000157081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972991,0.0009208702,0.000128566,0.00008704625,0.0005814272,0.0001091082,0.000002519063,0.00002534038,0.0008459596],"genre_scores_gemma":[0.9988492,0.00002482957,0.00009132878,0.0000653957,0.0002411808,0.00000222058,0.00001141953,0.000009437199,0.0007050419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006148492,"threshold_uncertainty_score":0.5139973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254396072115797,"score_gpt":0.2556478060043038,"score_spread":0.2331038452831458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}