{"id":"W2041500460","doi":"10.1038/sj.cgt.7700619","title":"Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase","year":2003,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Montreal General Hospital","funders":"National Institutes of Health; Cancer Research Society","keywords":"Biology; Haematopoiesis; Population; Viral vector; Cancer research; Molecular biology; Stem cell; Cell biology; Medicine; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003244696,0.0003940259,0.0003997834,0.0004266373,0.0002059489,0.0004447465,0.0003169417,0.0003812988,0.002268543],"category_scores_gemma":[0.0001701978,0.0002743854,0.0004588442,0.0002673143,0.0002486747,0.0002046339,0.0002425333,0.0007533385,0.0005607452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296923,"about_ca_system_score_gemma":0.0002325446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300659,"about_ca_topic_score_gemma":0.001487464,"domain_scores_codex":[0.9996339,0.0000844348,0.00004449915,0.00006787666,0.00008377581,0.00008549944],"domain_scores_gemma":[0.9996594,0.0001032182,0.00005921091,0.00007192424,0.00003246641,0.00007377607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000878247,0.00001556758,0.00009871694,0.000005573846,0.000003662044,0.00003828293,0.00001172336,0.00002517418,0.9993339,0.00007532634,0.00001819238,0.000285929],"study_design_scores_gemma":[0.000007976805,0.0001329613,0.002033541,0.000001703195,0.00001032739,0.0001942894,0.00001438871,0.0003208498,0.9965833,0.00002004305,0.0006780918,0.000002582306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924859,0.0008876326,0.00340755,0.0001021725,0.00006951646,0.00004695795,0.0008318258,0.0001107205,0.002057595],"genre_scores_gemma":[0.9912443,0.0003904268,0.002035642,0.00005759395,0.00001247654,0.0000335548,0.001032531,0.0000585396,0.005134862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002268543,"threshold_uncertainty_score":0.007589042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005313276386180826,"score_gpt":0.2142284218195903,"score_spread":0.2089151454334094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}