{"id":"W2041500460","doi":"10.1038/sj.cgt.7700619","title":"Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase","year":2003,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Montreal General Hospital","funders":"National Institutes of Health; Cancer Research Society","keywords":"Biology; Haematopoiesis; Population; Viral vector; Cancer research; Molecular biology; Stem cell; Cell biology; Medicine; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184543,0.0002648491,0.0003190968,0.00006771944,0.0001330089,0.00003613344,0.00007233561,0.00008810766,0.000005311053],"category_scores_gemma":[0.000005550409,0.0002019537,0.0000603838,0.0002086493,0.0001102243,0.00001632365,0.00001119451,0.0001207776,6.527921e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002993106,"about_ca_system_score_gemma":0.0001588234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001155399,"about_ca_topic_score_gemma":0.000186097,"domain_scores_codex":[0.9986795,0.000157709,0.0002672955,0.0004512297,0.0001331298,0.0003111534],"domain_scores_gemma":[0.9995688,0.00002598343,0.0000535711,0.0001988365,0.00003546368,0.0001173752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00335783,0.00004773738,0.0009874143,0.00007914189,0.00009342949,0.00001344156,0.0007507083,0.0000649785,0.9939966,0.000004693512,0.000003961566,0.0006000596],"study_design_scores_gemma":[0.003026773,0.000510279,0.0009004546,0.0001205116,0.00005431429,0.00004385443,0.00007447469,0.00003308362,0.994775,0.00003351499,0.0001775837,0.0002501524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793314,0.01942568,0.0004421708,0.0001626174,0.00004307634,0.000514806,0.00006575652,0.000009789625,0.000004742765],"genre_scores_gemma":[0.9963224,0.002602605,0.0007368171,0.0001660726,0.00003302277,0.00006385918,0.0000203605,0.00004083215,0.00001403454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01699104,"threshold_uncertainty_score":0.8235431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005313276386180826,"score_gpt":0.2142284218195903,"score_spread":0.2089151454334094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}