{"id":"W2041507320","doi":"10.1371/journal.pone.0056423","title":"Human Concentrative Nucleoside Transporter 3 Transfection with Ultrasound and Microbubbles in Nucleoside Transport Deficient HEK293 Cells Greatly Increases Gemcitabine Uptake","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation; Cancer Research Institute","keywords":"Gemcitabine; Efflux; Nucleoside; Transfection; HEK 293 cells; Nucleoside transporter; Chemistry; Pharmacology; Biology; Transporter; Biochemistry; Cancer; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004568131,0.0002834458,0.0005781279,0.000188218,0.0002223082,0.0005010553,0.0002752285,0.000438076,0.001635759],"category_scores_gemma":[0.0003495725,0.0002093393,0.0004547278,0.0002754955,0.0004110156,0.0003330793,0.0002517797,0.0008403967,0.000704688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006160068,"about_ca_system_score_gemma":0.0003364144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092718,"about_ca_topic_score_gemma":0.001243818,"domain_scores_codex":[0.9995104,0.000102964,0.00006366131,0.000111155,0.000147698,0.0000641173],"domain_scores_gemma":[0.9997694,0.00009200411,0.00004663106,0.00003275384,0.00003236268,0.00002686616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006139535,0.00001378092,0.00006579647,0.00001739772,0.000003820971,0.00002386852,0.00003019083,0.00004731022,0.9991154,0.0001185348,0.00003515891,0.0004673784],"study_design_scores_gemma":[0.000009475479,0.0001082746,0.0005211536,0.000001889537,0.00001094668,0.00007728724,0.00001355308,0.001068266,0.9964888,0.00002113157,0.001675265,0.00000399195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707954,0.001197056,0.02342892,0.0002931326,0.00008392907,0.0001120444,0.000842996,0.0004297269,0.002816825],"genre_scores_gemma":[0.9689379,0.001036747,0.02095145,0.0001462524,0.00002527572,0.0001678981,0.002267519,0.000187012,0.006279923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635759,"threshold_uncertainty_score":0.005472183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02995432138603217,"score_gpt":0.248122199086596,"score_spread":0.2181678777005638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}