{"id":"W2041535798","doi":"10.1038/nature09504","title":"Selective inhibition of BET bromodomains","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4296,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Public Health Service; Cancer Research UK; Wellcome Trust","keywords":"Bromodomain; BRD4; Epigenetics; Chromatin; BET inhibitor; Small molecule; Histone; Fusion protein; Chemistry; Binding site; Computational biology; Acetylation; Biology; Cell biology; Cancer research; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178786,0.0003768419,0.000341981,0.0002583399,0.0001841872,0.0003370391,0.0003160076,0.000274214,0.001706315],"category_scores_gemma":[0.000152176,0.0001534453,0.0002209031,0.0002058289,0.0001868435,0.0001803811,0.0001662375,0.0005738441,0.0004081651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004906127,"about_ca_system_score_gemma":0.0002033816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004411611,"about_ca_topic_score_gemma":0.001110836,"domain_scores_codex":[0.9998493,0.00001547565,0.00001071002,0.00002642957,0.00004618683,0.00005181325],"domain_scores_gemma":[0.999933,0.00001932172,0.00001414542,0.00001037015,0.000007528754,0.00001557963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004832085,0.00008878364,0.0001058161,0.00007862502,0.00001979074,0.00005117921,0.00001248561,0.0002273152,0.9914929,0.001075973,0.0003701341,0.005993871],"study_design_scores_gemma":[0.00003848765,0.0001338347,0.0005135671,0.000002943366,0.0000106586,0.0001340924,0.000004605329,0.0007865851,0.9929974,0.00008730662,0.005286862,0.000003615495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648622,0.009587024,0.01089655,0.0004388493,0.0002594491,0.0001210199,0.0009367209,0.0003968241,0.01250136],"genre_scores_gemma":[0.9842044,0.003501349,0.003464427,0.0001271318,0.00003126787,0.00006471579,0.0006029269,0.00004702113,0.007956692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706315,"threshold_uncertainty_score":0.005708158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00277973780960531,"score_gpt":0.2342449400341446,"score_spread":0.2314652022245393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}