{"id":"W2041538681","doi":"10.1002/ijc.21071","title":"Pharmaceutical‐mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide","year":2005,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Western University","funders":"","keywords":"Temozolomide; Cytotoxic T cell; Apoptosis; Cancer research; Glioma; Chemotherapy; Carmustine; DNA damage; Sensitization; Cell cycle checkpoint; Pharmacology; Cell cycle; Chemistry; Medicine; Biology; Immunology; DNA; Internal medicine; Cyclophosphamide; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820849,0.0001025898,0.0002403323,0.0003438709,0.00001351842,0.00001400975,0.00009747911,0.00006596605,0.000207782],"category_scores_gemma":[0.0001535471,0.00009112273,0.00008529576,0.0001534384,0.00005156718,0.0001280385,0.00003558459,0.0002175481,0.000009787149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003664168,"about_ca_system_score_gemma":0.0002155169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004736466,"about_ca_topic_score_gemma":0.00002391342,"domain_scores_codex":[0.9986939,0.00002744681,0.0004619315,0.0001133784,0.0005835455,0.0001197537],"domain_scores_gemma":[0.9984785,0.00008759229,0.0003054302,0.00007236185,0.0008861576,0.0001699139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001336434,0.00008743856,0.0006610932,0.00001615532,0.0004276877,0.0001214576,0.000251289,0.0007494614,0.9536815,0.00005129146,0.002517641,0.04009851],"study_design_scores_gemma":[0.003261051,0.0002064386,0.004956608,0.0003661538,0.0001400668,0.0004648264,0.00005773746,0.0007758902,0.9453347,0.0000358133,0.04430689,0.00009382514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863167,0.001420288,0.001142733,0.009613072,0.0007975828,0.0001391593,0.00002990087,0.000009733875,0.0005308622],"genre_scores_gemma":[0.995669,0.0005962822,0.001359519,0.001506567,0.0007565214,0.000003264996,0.00000371981,0.00001725022,0.00008787368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04178925,"threshold_uncertainty_score":0.3715877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138802121000495,"score_gpt":0.3418812886880053,"score_spread":0.3280010765879558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}