{"id":"W2041538681","doi":"10.1002/ijc.21071","title":"Pharmaceutical‐mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide","year":2005,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Western University","funders":"","keywords":"Temozolomide; Cytotoxic T cell; Apoptosis; Cancer research; Glioma; Chemotherapy; Carmustine; DNA damage; Sensitization; Cell cycle checkpoint; Pharmacology; Cell cycle; Chemistry; Medicine; Biology; Immunology; DNA; Internal medicine; Cyclophosphamide; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009906606,0.0002857145,0.000359779,0.0002924552,0.0001161998,0.0002228203,0.0001665067,0.0002187005,0.0008202271],"category_scores_gemma":[0.0001126665,0.0001212864,0.000187067,0.000226702,0.0001851996,0.0001132403,0.000144714,0.000449848,0.00018681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222061,"about_ca_system_score_gemma":0.0001954085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001536748,"about_ca_topic_score_gemma":0.002420199,"domain_scores_codex":[0.9998823,0.00002118797,0.00001034159,0.00001269838,0.00003394914,0.00003941957],"domain_scores_gemma":[0.9999589,0.000007338462,0.00001082638,0.000009430432,0.000004801912,0.000008696507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001460582,0.00008862309,0.0001515293,0.00003121451,0.000007663141,0.0000354715,0.00001627486,0.0001139499,0.9963157,0.00008783167,0.00007533627,0.002930309],"study_design_scores_gemma":[0.00003361077,0.0008408512,0.003198687,0.000003857448,0.00001451909,0.0001082251,0.00001483233,0.0006663973,0.9931296,0.00003561585,0.001951273,0.000002573445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959798,0.001449122,0.0008886645,0.00009654074,0.0000244365,0.00003987375,0.0001677949,0.00006225659,0.001291586],"genre_scores_gemma":[0.9964473,0.001133529,0.001052528,0.00004191393,0.000008184687,0.00002879392,0.000420478,0.000008691948,0.0008586307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536748,"threshold_uncertainty_score":0.003055573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138802121000495,"score_gpt":0.3418812886880053,"score_spread":0.3280010765879558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}