{"id":"W2041542117","doi":"10.1016/j.jaci.2012.12.914","title":"Impaired in Vitro Capacity to Undergo IgG Isotype Class-Switching (ICS) in Response to Interleukin-21 (IL21) Stimulation in Common Variable Immunodeficiency (CVID)","year":2013,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Children's Hospital; Christie (Canada); McGill University Health Centre","funders":"","keywords":"Common variable immunodeficiency; Immunology; Hypogammaglobulinemia; Immunoglobulin class switching; CD8; Interleukin 4; Medicine; Antibody; Cytokine; Immune system; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003164357,0.0003180496,0.0003873646,0.0004063282,0.0001860657,0.0005376849,0.0003255665,0.0003920001,0.002268441],"category_scores_gemma":[0.0006719457,0.0002207564,0.0002765162,0.0002004075,0.0002748441,0.0001768136,0.0003113096,0.0007423575,0.0004371787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863633,"about_ca_system_score_gemma":0.0002337807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001966266,"about_ca_topic_score_gemma":0.0008461835,"domain_scores_codex":[0.9995871,0.00008989913,0.00005771807,0.00005597738,0.00007552923,0.0001338241],"domain_scores_gemma":[0.9995866,0.000130792,0.0000544442,0.00007598936,0.00004511302,0.0001069092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001196661,0.0002504983,0.009529665,0.00007679093,0.00002633395,0.0005568438,0.0001250402,0.0001847793,0.9842086,0.00019447,0.000178312,0.003472049],"study_design_scores_gemma":[0.0001148536,0.002826746,0.3160755,0.00003656986,0.0001447481,0.007799204,0.0003500419,0.002874499,0.6657217,0.0004708921,0.003558081,0.00002725235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998535,0.0005187187,0.0001658849,0.00001757534,0.00001308105,0.000009507095,0.0001981095,0.00001596835,0.0005260775],"genre_scores_gemma":[0.9987506,0.0001660562,0.000115298,0.00002002591,0.000005747339,0.000008936187,0.0004540344,0.000005792383,0.0004735196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002268441,"threshold_uncertainty_score":0.007588685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156055114104152,"score_gpt":0.2875203687056685,"score_spread":0.265959817564627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}