{"id":"W2041551971","doi":"10.1371/journal.pbio.0030378","title":"The Case for Selection at CCR5-Δ32","year":2005,"lang":"en","type":"article","venue":"PLoS Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; Damon Runyon Cancer Research Foundation; Cancer Research Institute","keywords":"Biology; Allele; Linkage disequilibrium; Genetics; Locus (genetics); Evolutionary biology; Balancing selection; Chemokine receptor CCR5; Chemokine receptor; Gene; Haplotype; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001647419,0.0002432797,0.0004035769,0.0002681879,0.0007157012,0.001207164,0.0006170963,0.001131736,0.005744353],"category_scores_gemma":[0.003106295,0.0001467693,0.0002861073,0.0002968076,0.001224953,0.001085039,0.0005727576,0.001434862,0.0008516496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003965092,"about_ca_system_score_gemma":0.0004246704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005375,"about_ca_topic_score_gemma":0.001042099,"domain_scores_codex":[0.99911,0.0001531069,0.00004172057,0.0003527067,0.0001624319,0.0001799439],"domain_scores_gemma":[0.9982617,0.000707998,0.0002353384,0.0003140859,0.0001852671,0.0002955011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002236691,0.0002879643,0.2196563,0.001138648,0.0004721385,0.007274719,0.002046237,0.002176214,0.328829,0.1684201,0.02126296,0.2461991],"study_design_scores_gemma":[0.0005664059,0.002093775,0.4449795,0.0005980631,0.0005182463,0.02323905,0.00426533,0.009374938,0.07892036,0.1774244,0.2577544,0.0002654727],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8805682,0.01526683,0.01913474,0.03080501,0.001856669,0.00006850086,0.0004678422,0.0003138557,0.05151839],"genre_scores_gemma":[0.9874657,0.001868173,0.002214378,0.004914058,0.000298629,0.00002171181,0.0001830077,0.00003360086,0.00300065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005744353,"threshold_uncertainty_score":0.01921684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02575154229301401,"score_gpt":0.2893364381904743,"score_spread":0.2635848958974603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}