{"id":"W2041574932","doi":"10.4161/cbt.5.8.3274","title":"Important differences between topoisomerase-I and -II targeting agents","year":2006,"lang":"en","type":"letter","venue":"Cancer Biology & Therapy","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba","funders":"","keywords":"Topoisomerase; Biology; Cancer research; Chemistry; Pharmacology; Cell biology; Medicine; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001559654,0.0006651452,0.001100698,0.0003404654,0.001181768,0.001433782,0.001285895,0.01809096,0.004504955],"category_scores_gemma":[0.006366486,0.0003618506,0.0008956066,0.0003570979,0.001309308,0.001365062,0.0004799272,0.01594754,0.003339661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002307612,"about_ca_system_score_gemma":0.001157458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001599825,"about_ca_topic_score_gemma":0.002579651,"domain_scores_codex":[0.99887,0.0002107372,0.0001687556,0.0001772545,0.0004185968,0.000154719],"domain_scores_gemma":[0.9975464,0.001313928,0.000233479,0.00007806418,0.0004870601,0.0003411043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000552695,0.00008364172,0.0005327746,0.000333529,0.00005126387,0.004659394,0.0001573263,0.000134748,0.003120915,0.004152298,0.958576,0.02764541],"study_design_scores_gemma":[0.0003537769,0.0002604779,0.001651312,0.000125296,0.00008381937,0.003692165,0.0002149612,0.0003539698,0.003369001,0.004477468,0.9853551,0.00006262748],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.002148977,0.005312313,0.0004208759,0.9098358,0.07868263,0.00003043293,0.0001165859,0.00008830876,0.003364096],"genre_scores_gemma":[0.01980797,0.005211716,0.0006410942,0.8254309,0.1371411,0.00005990898,0.00007086389,0.00004228571,0.01159412],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.01809096,"threshold_uncertainty_score":0.01674294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0301252613927418,"score_gpt":0.2932579225622819,"score_spread":0.2631326611695401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}