{"id":"W2041574932","doi":"10.4161/cbt.5.8.3274","title":"Important differences between topoisomerase-I and -II targeting agents","year":2006,"lang":"en","type":"letter","venue":"Cancer Biology & Therapy","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba","funders":"","keywords":"Topoisomerase; Biology; Cancer research; Chemistry; Pharmacology; Cell biology; Medicine; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001480504,0.0005191303,0.0005674776,0.00008110949,0.0002347297,0.00003510798,0.0003714656,0.001216205,0.0001407258],"category_scores_gemma":[0.000003875347,0.000427226,0.0001770803,0.00007568479,0.0002160549,0.000002850355,0.0001503018,0.0005668924,0.000002139673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000387011,"about_ca_system_score_gemma":0.0001516172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003810539,"about_ca_topic_score_gemma":0.00004359398,"domain_scores_codex":[0.9978467,0.0001117814,0.0004376542,0.0008804652,0.0001201728,0.0006032407],"domain_scores_gemma":[0.999101,0.00002261392,0.0003341154,0.0003949345,0.00007586332,0.00007143723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000779437,0.00004237317,0.05401661,0.00005443633,0.001106817,0.00002285969,0.0001070299,6.978018e-7,0.2579318,0.00003137817,0.6522715,0.0343365],"study_design_scores_gemma":[0.0006912497,0.0006016591,0.001863736,0.00002451397,0.0000631451,0.0000032267,0.000009247857,0.000002218866,0.02043884,0.0009759864,0.9747652,0.0005609517],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.8622626,0.06646211,0.0002036389,0.06790601,0.001435379,0.0005782844,0.0009480385,0.00004460379,0.0001593484],"genre_scores_gemma":[0.3834409,0.07320517,0.0002613116,0.511701,0.01893668,0.0004719854,0.007108937,0.0002338316,0.004640191],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4788217,"threshold_uncertainty_score":0.999818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0301252613927418,"score_gpt":0.2932579225622819,"score_spread":0.2631326611695401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}