{"id":"W2041593863","doi":"10.1038/nchem.1062","title":"Contemporary strategies for peptide macrocyclization","year":2011,"lang":"en","type":"review","venue":"Nature Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1068,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptide; Cyclic peptide; Combinatorial chemistry; Drug discovery; Ring (chemistry); Molecule; Nanotechnology; Small molecule; Nanomaterials; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215749,0.001474578,0.001297467,0.001400776,0.0005810141,0.001354648,0.001600669,0.001147362,0.003258374],"category_scores_gemma":[0.001019651,0.0007072988,0.0004159763,0.001984478,0.001635502,0.002656622,0.001667798,0.002707675,0.002723721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00114363,"about_ca_system_score_gemma":0.0009899235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007027765,"about_ca_topic_score_gemma":0.001243626,"domain_scores_codex":[0.9995973,0.00005692839,0.00004108411,0.00008543616,0.0001517615,0.00006742983],"domain_scores_gemma":[0.9996701,0.0001568883,0.00004759805,0.00003024576,0.00006409368,0.00003103379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008496374,0.00009875885,0.00009725054,0.007194571,0.00004710297,0.0002434044,0.00009237497,0.001917252,0.01480368,0.02976207,0.01907209,0.9265865],"study_design_scores_gemma":[0.00002471457,0.0001389399,0.0002059002,0.0007583783,0.00003648301,0.0006598872,0.00004153328,0.0004626874,0.01083586,0.009856446,0.976949,0.00003013061],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007700352,0.9870581,0.005786804,0.0003835663,0.0005913382,0.00002244989,0.0000343589,0.00007600823,0.005277343],"genre_scores_gemma":[0.005037822,0.9868156,0.003703273,0.0004416985,0.0003935125,0.00006161755,0.00007499202,0.00002093802,0.00345042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003258374,"threshold_uncertainty_score":0.01090038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.028077322387928,"score_gpt":0.3168296954450466,"score_spread":0.2887523730571186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}