{"id":"W2041603493","doi":"10.1074/jbc.m010590200","title":"The Gab1 Docking Protein Links the B Cell Antigen Receptor to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and to the SHP2 Tyrosine Phosphatase","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia","funders":"","keywords":"Protein tyrosine phosphatase; Protein kinase B; Docking (animal); Receptor tyrosine kinase; Cell biology; Chemistry; Macromolecular docking; Cancer research; Phosphatidylinositol; ROR1; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Biochemistry; Receptor; Biology; Platelet-derived growth factor receptor; Protein structure; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001507857,0.0003433564,0.0002834916,0.00001273646,0.0008178825,0.0002377414,0.001365644,0.000304909,0.00005264146],"category_scores_gemma":[0.001049742,0.0001369669,0.000207953,0.0002653203,0.0002674422,0.00001147932,0.000555411,0.0007271112,0.00001447476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003460979,"about_ca_system_score_gemma":0.0001153912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001803022,"about_ca_topic_score_gemma":0.000006006561,"domain_scores_codex":[0.9978769,0.0001859212,0.000643866,0.0004045254,0.0003553115,0.0005335219],"domain_scores_gemma":[0.9981235,0.0002215486,0.0004658737,0.000678729,0.0002591854,0.0002512196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006407221,0.0000822114,0.00079627,0.00001539374,0.00006080184,0.00002556963,0.00006662292,0.0002043998,0.9794712,0.00004631354,0.008851126,0.009739333],"study_design_scores_gemma":[0.0002854223,0.0003286872,0.0001884063,0.00005967656,0.00001597974,0.00008214476,0.0001883928,0.000010015,0.7230737,0.00004399164,0.2755532,0.0001704663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9259369,0.05834709,0.0006513941,0.01383763,0.0001979419,0.0008050564,0.0001109659,0.00001291948,0.0001001053],"genre_scores_gemma":[0.994213,0.001361275,0.000608495,0.002124838,0.001282773,0.00008049339,0.00003966716,0.00002561679,0.00026384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.266702,"threshold_uncertainty_score":0.6290573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321773198773334,"score_gpt":0.2370638807513471,"score_spread":0.2238461487636138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}