{"id":"W2041607260","doi":"10.1182/blood-2013-04-497354","title":"Robust ZFN-mediated genome editing in adult hemophilic mice","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Zinc finger nuclease; Genome editing; Biology; Zinc finger; Genetic enhancement; Genome; Gene; Computational biology; Transcription activator-like effector nuclease; DNA; Genetics; Cell biology; Virology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005127826,0.0001102258,0.00009194836,0.00003911951,0.00002204967,0.0000168148,0.0001199364,0.0001025221,0.00004043401],"category_scores_gemma":[0.00008843781,0.0001148343,0.0000371063,0.00008515095,0.00001661145,0.000002534895,0.00005977658,0.00007955058,0.00005915464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004371455,"about_ca_system_score_gemma":0.00001446366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006286087,"about_ca_topic_score_gemma":0.00005202418,"domain_scores_codex":[0.9992994,0.00001212329,0.0001533144,0.0002230937,0.00006637186,0.0002456906],"domain_scores_gemma":[0.9996721,0.000007492124,0.00002564946,0.0001773404,0.00005078863,0.00006663109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000001892538,0.00007440791,0.003706691,0.00001960877,0.00001812675,0.000004197181,0.00004424477,0.0007219663,0.9949499,0.000003120889,0.0002348235,0.0002210717],"study_design_scores_gemma":[0.003743273,0.000254384,0.09514868,0.00004982638,0.00004339658,0.00007532131,0.000386729,0.001430361,0.8925862,0.00003376248,0.005535506,0.0007125254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975386,0.000645767,0.0004892784,0.0001316763,0.00008692387,0.0001443004,0.000006954283,0.00001729806,0.0009391555],"genre_scores_gemma":[0.997933,0.00009291204,0.001057009,0.0002007868,0.0004262338,0.00003583624,0.0000900916,0.00002056013,0.0001435946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1023636,"threshold_uncertainty_score":0.4682809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005392661695598176,"score_gpt":0.2157135006048714,"score_spread":0.2103208389092732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}