{"id":"W2041620528","doi":"10.1097/nen.0b013e31802d9011","title":"Upregulation of Hypoxia-Inducible Factor (HIF)-1α and HIF-2α in Leptomeningeal Vascular Malformations of Sturge-Weber Syndrome","year":2007,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Vascular Malformations and Hemangiomas","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Angiogenesis; Vascular endothelial growth factor; Hypoxia (environmental); Immunohistochemistry; Pathology; Downregulation and upregulation; Hypoxia-inducible factors; Vascular endothelial growth factor A; Biology; In situ hybridization; Neuropilin 1; Neovascularization; HIF1A; Medicine; Cancer research; Gene expression; Chemistry; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052969,0.0002994638,0.0001988852,0.0009425769,0.000158016,0.0001701366,0.00009305591,0.0002336713,0.0006951583],"category_scores_gemma":[0.0004062339,0.0001809254,0.0001900054,0.0002814104,0.000372358,0.0001641917,0.0001524363,0.0001696385,0.00008722026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001966325,"about_ca_system_score_gemma":0.0000850524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005852046,"about_ca_topic_score_gemma":0.0005283673,"domain_scores_codex":[0.9999299,0.00001344463,0.00001035574,0.00002069167,0.00001357092,0.000011941],"domain_scores_gemma":[0.9998389,0.0000349997,0.00007729988,0.000006701147,0.000009555174,0.00003237691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009272562,0.00008376898,0.4336707,0.0001504056,0.0001267991,0.1015229,0.001152835,0.0007468662,0.4391733,0.0002374855,0.0002266675,0.0219811],"study_design_scores_gemma":[0.0000288237,0.0004114323,0.8634806,0.00001404004,0.00008849627,0.1112503,0.0002405761,0.0008188749,0.022771,0.0002879743,0.0005891956,0.00001869555],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995461,0.0001176072,0.0001899703,0.000009637722,0.000001429208,0.000001818041,0.00001486181,0.000006427691,0.0001121272],"genre_scores_gemma":[0.9995642,0.000111309,0.0001841319,0.000007303846,0.000004906293,0.000003568373,0.00003436729,0.000001886371,0.00008829874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009425769,"threshold_uncertainty_score":0.002325594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640531169235869,"score_gpt":0.2819529627491762,"score_spread":0.2655476510568175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}