{"id":"W2041631632","doi":"10.1097/fpc.0b013e3283498ecf","title":"Genetic epidemiology of induced CYP3A4 activity","year":2011,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"CYP3A4; Pharmacogenetics; Genetic variation; Population; Biology; Drug metabolism; Heritability; Genetic variability; Twin study; Pharmacology; Genetics; Cytochrome P450; Drug; Medicine; Metabolism; Environmental health; Biochemistry; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001145426,0.0004378663,0.0007156155,0.0002148121,0.0002017641,0.000005188789,0.0004830412,0.0003918715,0.0008277604],"category_scores_gemma":[0.00009141869,0.000446405,0.0001871505,0.0002325069,0.0004237611,0.00005986353,0.0003309923,0.0006743934,0.00005027228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003462481,"about_ca_system_score_gemma":0.0001376452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009641054,"about_ca_topic_score_gemma":0.000008106513,"domain_scores_codex":[0.9969838,0.0006853162,0.000803936,0.0006076467,0.0001363994,0.0007828875],"domain_scores_gemma":[0.9980173,0.0003764973,0.0004571036,0.0003620447,0.0001647448,0.0006223721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005982587,0.0005791971,0.1023959,0.0001017864,0.0004996472,0.00002810724,0.001702811,0.0002155371,0.673609,0.001229125,0.0002342026,0.2188064],"study_design_scores_gemma":[0.003308308,0.0003176625,0.1866578,0.000009083869,0.0008234791,0.00009211188,0.00007296835,0.01069683,0.7428302,0.005987827,0.04837879,0.0008249283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844925,0.00812234,0.0007518629,0.0001117987,0.001396453,0.0005019627,0.0001433098,0.00005112792,0.004428586],"genre_scores_gemma":[0.9814985,0.01072832,0.005834534,0.001388399,0.0003407449,0.00004418801,0.000005790077,0.00006296412,0.00009658021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2179815,"threshold_uncertainty_score":0.9997988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3375756093859221,"score_gpt":0.4534916952181803,"score_spread":0.1159160858322582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}