{"id":"W2041631632","doi":"10.1097/fpc.0b013e3283498ecf","title":"Genetic epidemiology of induced CYP3A4 activity","year":2011,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"CYP3A4; Pharmacogenetics; Genetic variation; Population; Biology; Drug metabolism; Heritability; Genetic variability; Twin study; Pharmacology; Genetics; Cytochrome P450; Drug; Medicine; Metabolism; Environmental health; Biochemistry; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238049,0.000343704,0.0004507964,0.0008788991,0.0004226182,0.000397857,0.0003881771,0.0005022807,0.001533994],"category_scores_gemma":[0.003530538,0.0002286193,0.0004212989,0.001235714,0.0006073224,0.0002012443,0.0005682327,0.0004607809,0.0001541176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249525,"about_ca_system_score_gemma":0.0002161676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00342364,"about_ca_topic_score_gemma":0.001825226,"domain_scores_codex":[0.9980153,0.000890741,0.0001507609,0.0005802719,0.0002645442,0.00009840971],"domain_scores_gemma":[0.9979752,0.0006779237,0.0007371583,0.0002535116,0.0001950805,0.0001612012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000292092,0.00003932954,0.9917679,0.00002224206,0.0002273541,0.0002413039,0.0001084749,0.0002449408,0.003326357,0.0003259239,0.00006824118,0.003335717],"study_design_scores_gemma":[0.000007844419,0.0001824052,0.997001,0.00001025072,0.0001076983,0.001060419,0.0000709473,0.0006547074,0.0004670084,0.0002493906,0.000182225,0.000006141028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974317,0.0005704939,0.001264874,0.00005735567,0.000006315942,0.00001331476,0.0002996883,0.00001200993,0.0003442952],"genre_scores_gemma":[0.9990125,0.0001758216,0.000547232,0.000009949195,0.000008258154,0.000007000614,0.0001638034,0.000004643923,0.00007090608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00342364,"threshold_uncertainty_score":0.006807387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3375756093859221,"score_gpt":0.4534916952181803,"score_spread":0.1159160858322582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}