{"id":"W204164459","doi":"10.1038/76282","title":"Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor","year":2000,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":376,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Elastin; Tenascin C; Pulmonary hypertension; Elastase; Pulmonary artery; Extracellular matrix; Medicine; Tenascin; Internal medicine; Lung; Endocrinology; Extracellular; Cardiology; Pathology; Biology; Cell biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784578,0.0001508038,0.000230733,0.00005041452,0.00002381297,0.000001639416,0.0001176551,0.0002522031,0.00019523],"category_scores_gemma":[0.00006061847,0.0001190939,0.00004207708,0.0001251581,0.0000791769,0.000004683448,0.00004260392,0.0002973207,0.000006666751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001040879,"about_ca_system_score_gemma":0.00002664673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000512803,"about_ca_topic_score_gemma":0.00001148245,"domain_scores_codex":[0.9990243,0.00005551844,0.0002477859,0.0002845494,0.000201066,0.0001868062],"domain_scores_gemma":[0.9995573,0.000008603099,0.00005399943,0.0002493449,0.00004822413,0.00008248763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003931093,0.00008193762,0.00004082524,0.00002468922,0.000009583808,0.00006952797,0.0000110632,0.000001535056,0.9712376,0.000009997529,0.0238568,0.004263333],"study_design_scores_gemma":[0.001278778,0.0007167809,0.0001204639,0.0001341051,0.00001257542,0.00007112875,0.00002640736,0.00007810188,0.8883299,0.00004017754,0.1090627,0.000128874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920805,0.00553647,0.00003498738,0.0009344408,0.0001997678,0.000217629,0.0001077728,0.000009434833,0.0008789808],"genre_scores_gemma":[0.9965948,0.0003226782,0.0001820976,0.001153143,0.00046375,0.00000777288,0.000779803,0.00001668081,0.0004792157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08520588,"threshold_uncertainty_score":0.4856508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005540831322203349,"score_gpt":0.2235917256508999,"score_spread":0.2180508943286966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}