{"id":"W2041679498","doi":"10.1021/bi001941r","title":"Characterization of RNA Aptamer Binding by the Wilms' Tumor Suppressor Protein WT1","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"RNA; Zinc finger; Nucleic acid; DNA; Dissociation constant; Chemistry; Divalent; Aptamer; Binding site; Isothermal titration calorimetry; Biophysics; Molecular biology; Crystallography; Biochemistry; Biology; Transcription factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311172,0.0004604328,0.000404052,0.0005107577,0.0001211129,0.0002614686,0.0003330221,0.0003310911,0.0008939706],"category_scores_gemma":[0.0006473486,0.0001745518,0.0002347617,0.0002767103,0.0002125936,0.0001286357,0.0001161941,0.0003915305,0.0006113231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140233,"about_ca_system_score_gemma":0.00009983544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007930388,"about_ca_topic_score_gemma":0.0007891543,"domain_scores_codex":[0.9996511,0.00004927561,0.00001791393,0.00007867757,0.0001653235,0.00003781675],"domain_scores_gemma":[0.9996608,0.0001232688,0.00008351649,0.00001720153,0.00006018531,0.00005500942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002053234,0.000006911744,0.0002517494,0.00001483899,0.000002701984,0.00001715228,0.000007648422,0.0001037068,0.9990349,0.00001263277,0.000008289269,0.0005188916],"study_design_scores_gemma":[0.000003748003,0.00009787951,0.007269042,0.000002404498,0.000006939211,0.0002163624,0.00001560319,0.003122132,0.9884328,0.00001761543,0.0008098741,0.000005585819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853799,0.0009754152,0.01217224,0.0000460857,0.000008465516,0.00003740475,0.000619241,0.0001461475,0.0006150051],"genre_scores_gemma":[0.985742,0.0006291572,0.009031746,0.00005908269,0.000008747687,0.00007250604,0.002078112,0.0000571018,0.002321649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008939706,"threshold_uncertainty_score":0.002990663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00435782029488497,"score_gpt":0.2039500489739155,"score_spread":0.1995922286790306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}