{"id":"W2041679498","doi":"10.1021/bi001941r","title":"Characterization of RNA Aptamer Binding by the Wilms' Tumor Suppressor Protein WT1","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"RNA; Zinc finger; Nucleic acid; DNA; Dissociation constant; Chemistry; Divalent; Aptamer; Binding site; Isothermal titration calorimetry; Biophysics; Molecular biology; Crystallography; Biochemistry; Biology; Transcription factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006788361,0.0001246504,0.0000971069,0.0000105648,0.00006220338,0.00001470444,0.0002022517,0.0001358682,0.0000420199],"category_scores_gemma":[0.00002831271,0.00008827569,0.00007394917,0.00009434165,0.0001104419,0.000003182199,0.00005249004,0.00009298827,0.000006021008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001230343,"about_ca_system_score_gemma":0.00004949811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001097391,"about_ca_topic_score_gemma":3.043492e-7,"domain_scores_codex":[0.9992896,0.00001827,0.0001740648,0.0002241041,0.0001198392,0.000174093],"domain_scores_gemma":[0.9994957,0.000002870489,0.0001362437,0.0002633308,0.00005219602,0.00004966912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006415125,0.0000306412,0.0002042506,0.00003229503,0.00004134138,0.000001874005,0.00001072591,0.000001441638,0.9976016,0.000001735114,0.001573411,0.0004365749],"study_design_scores_gemma":[0.0002400645,0.00003967565,0.00007717712,0.00004192763,0.00001353725,0.0000213051,0.00003297635,0.00001367683,0.9851148,0.000002506162,0.01428044,0.0001219522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976704,0.0003933265,0.00006410424,0.0002508687,0.00006543133,0.0001460629,0.0000578102,0.000009435891,0.001342603],"genre_scores_gemma":[0.9927824,0.0001322538,0.00002143184,0.0001004482,0.0001732867,0.00003313657,0.0003441737,0.00001666828,0.00639619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01270703,"threshold_uncertainty_score":0.3599778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00435782029488497,"score_gpt":0.2039500489739155,"score_spread":0.1995922286790306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}