{"id":"W2041687360","doi":"10.1158/1535-7163.targ-13-a192","title":"Abstract A192: Role of O(6)-Methylguanine-DNA Methyltransferase in the Proliferation/Invasion Dichotomy and Differential Effect of FAK inhibitor Y11 based on expression of MGMT in Glioblastoma.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; U87; Cell growth; Focal adhesion; Gene knockdown; Methyltransferase; Regulator; DNA methyltransferase; Blot; Biology; Small hairpin RNA; Western blot; Glioblastoma; Cell culture; Phosphorylation; Molecular biology; Cell biology; DNA; Biochemistry; Methylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053782,0.0003614576,0.0003356847,0.0002360627,0.0001597147,0.0001702213,0.0001990981,0.000292919,0.001623292],"category_scores_gemma":[0.00006806345,0.0001208691,0.0003930524,0.0001994456,0.000173306,0.0001532012,0.0001083367,0.000433868,0.0003337904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993285,"about_ca_system_score_gemma":0.0002311194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001477448,"about_ca_topic_score_gemma":0.00131995,"domain_scores_codex":[0.9998846,0.00001693492,0.00001371654,0.00002151807,0.00002473507,0.0000383779],"domain_scores_gemma":[0.9999567,0.000006622751,0.000009146076,0.000003803703,0.000006626769,0.0000169709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009409132,0.0001847334,0.0003032129,0.00007316419,0.00001099842,0.00006877139,0.00001436231,0.00005101433,0.9959283,0.00006300648,0.0001589615,0.0022025],"study_design_scores_gemma":[0.000102717,0.002708408,0.007148272,0.000006995616,0.00004336262,0.0001978861,0.00002765949,0.0006036136,0.9872089,0.00002842871,0.001918588,0.000005244223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946333,0.002313575,0.000701758,0.0001268441,0.00008444297,0.0000579571,0.0006511462,0.00006201514,0.001368998],"genre_scores_gemma":[0.9932166,0.001455691,0.001195003,0.00006652793,0.00001875154,0.00008730465,0.001474133,0.00001616197,0.002469979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623292,"threshold_uncertainty_score":0.00543046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009265723989132292,"score_gpt":0.2654354382194276,"score_spread":0.2561697142302953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}