{"id":"W2041692547","doi":"10.1186/s13063-015-0724-z","title":"Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients with Acute Myocardial Infarction (IMPRESSION): study protocol for a randomized controlled trial","year":2015,"lang":"en","type":"article","venue":"Trials","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Ticagrelor; Medicine; Pharmacodynamics; P2Y12; Prasugrel; Morphine; Myocardial infarction; Pharmacokinetics; Placebo; Pharmacology; Anesthesia; Internal medicine; Percutaneous coronary intervention","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003865351,0.0001820397,0.002748,0.0001558884,0.00001690181,0.000006386951,0.00005519587,0.00005894429,0.000009001496],"category_scores_gemma":[0.00149041,0.0001031641,0.0003980864,0.0001287995,0.0001012796,0.00006280362,0.00001834198,0.0000845807,2.762663e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002010796,"about_ca_system_score_gemma":0.0001435044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001011262,"about_ca_topic_score_gemma":2.732273e-7,"domain_scores_codex":[0.9970905,0.0009334675,0.001128968,0.000195631,0.0005255742,0.000125875],"domain_scores_gemma":[0.9979391,0.0007836455,0.0006255102,0.0001756588,0.0003711999,0.0001049381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9882544,0.002015871,0.002506093,0.00006565121,0.0039934,0.000004180794,0.0001877785,0.001151311,0.0005609654,0.000006690238,0.00002767067,0.001225966],"study_design_scores_gemma":[0.985815,0.005893744,0.00294169,0.0001265657,0.003654384,0.000001006818,0.00002547278,0.0004975058,0.0008629822,0.00003851152,0.00004528481,0.00009780597],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6556925,0.00001354779,0.00006252685,0.0000158794,0.00004788293,0.344125,0.00001940174,0.00000848372,0.0000148099],"genre_scores_gemma":[0.8285742,0.00001408434,0.00008068681,0.0000376965,0.0001032315,0.171155,0.00001066382,0.00001554735,0.000008828932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.17297,"threshold_uncertainty_score":0.420691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03994860260227202,"score_gpt":0.3885115933527619,"score_spread":0.3485629907504899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}