{"id":"W2041705668","doi":"10.1038/gt.2011.105","title":"Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; American Cancer Society; China Scholarship Council; National Center for Advancing Translational Sciences; University of Florida","keywords":"Transduction (biophysics); Biology; Signal transduction; Genetic enhancement; Tyrosine kinase; Mutant; Viral vector; Receptor tyrosine kinase; Cancer research; Transgene; Cancer cell; Molecular biology; Cell biology; Cancer; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005265112,0.0004425324,0.0003276193,0.000286472,0.0001996105,0.0004382492,0.0003102178,0.0003607069,0.0007742023],"category_scores_gemma":[0.0002199515,0.0002827039,0.0003925427,0.0002660453,0.0002625265,0.0003213771,0.0001800191,0.0007971753,0.0003581673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006791604,"about_ca_system_score_gemma":0.0007324775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001196658,"about_ca_topic_score_gemma":0.001702859,"domain_scores_codex":[0.9997801,0.00003708631,0.00002578513,0.00003364946,0.0000823716,0.00004110694],"domain_scores_gemma":[0.9998597,0.00002185322,0.00003694505,0.00001710721,0.00003321504,0.00003111335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006185847,0.00001787393,0.0001372949,0.00003208909,0.000006836932,0.00003071069,0.00001998025,0.0002474108,0.996166,0.0006541522,0.00009851791,0.00252723],"study_design_scores_gemma":[0.0000123005,0.00007347201,0.0005735202,0.000002231451,0.00001144027,0.0001428585,0.00000579107,0.001179813,0.9953979,0.00009937302,0.002494388,0.000007036062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7651983,0.002442895,0.2264181,0.0003658797,0.0001465287,0.0005057354,0.001402786,0.0008545269,0.002665294],"genre_scores_gemma":[0.8382674,0.001896488,0.1519992,0.0001155418,0.0000252489,0.0002249393,0.002167393,0.0002827601,0.00502099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196658,"threshold_uncertainty_score":0.004927695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357385452592154,"score_gpt":0.289095423903261,"score_spread":0.2455215693773394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}