{"id":"W2041705668","doi":"10.1038/gt.2011.105","title":"Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; American Cancer Society; China Scholarship Council; National Center for Advancing Translational Sciences; University of Florida","keywords":"Transduction (biophysics); Biology; Signal transduction; Genetic enhancement; Tyrosine kinase; Mutant; Viral vector; Receptor tyrosine kinase; Cancer research; Transgene; Cancer cell; Molecular biology; Cell biology; Cancer; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003057763,0.000151644,0.0002563424,0.00008617528,0.00004624731,0.000001900969,0.0002790214,0.0001214701,0.0005517371],"category_scores_gemma":[0.000001905565,0.0001378325,0.00009782158,0.0001333948,0.0001001925,0.000003470989,0.00002962606,0.00005609182,0.000001986703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001715463,"about_ca_system_score_gemma":0.0001963743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002041558,"about_ca_topic_score_gemma":0.00008687577,"domain_scores_codex":[0.9988652,0.00009004592,0.0003615436,0.0002555042,0.0002220533,0.0002055944],"domain_scores_gemma":[0.9992197,0.000003901213,0.0001828872,0.0003500752,0.0001956683,0.00004772656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002398349,0.0002943155,0.00001643139,0.00002937603,0.0001736703,3.83542e-7,0.001548644,0.0001126629,0.9892225,0.00003975392,0.00001229364,0.00615157],"study_design_scores_gemma":[0.001383365,0.002204856,0.000247142,0.00001344807,0.00001082664,5.346202e-7,0.00005125365,0.00001426564,0.9958049,0.00006324448,0.00007150428,0.0001346458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953454,0.001447954,0.002678818,0.00000520198,0.000105153,0.0003274777,0.00002113219,0.000006799258,0.00006203072],"genre_scores_gemma":[0.9908131,0.001925165,0.007017706,0.00001753174,0.00004998427,0.00003641736,0.0000247236,0.00002925281,0.00008606941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006582365,"threshold_uncertainty_score":0.6041135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357385452592154,"score_gpt":0.289095423903261,"score_spread":0.2455215693773394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}