{"id":"W2041800958","doi":"10.1007/s00432-005-0002-7","title":"The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through β-adrenergic transactivation of EGF receptors","year":2005,"lang":"en","type":"article","venue":"Journal of Cancer Research and Clinical Oncology","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Cell growth; Transactivation; Endocrinology; Internal medicine; Receptor; Signal transduction; Biology; Cancer research; Chemistry; Cell biology; Medicine; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151236,0.0002431273,0.0001647979,0.0002300935,0.0001608968,0.0002416683,0.000106188,0.0001613822,0.001304815],"category_scores_gemma":[0.0001197888,0.0001329934,0.0002946482,0.0001577515,0.0001815854,0.0001775033,0.0001662256,0.0003962409,0.0002435933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001670687,"about_ca_system_score_gemma":0.0001927774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005599686,"about_ca_topic_score_gemma":0.001360905,"domain_scores_codex":[0.9998994,0.00002336904,0.000008818698,0.00001497106,0.00002076021,0.00003264508],"domain_scores_gemma":[0.9999177,0.00002587665,0.00001523165,0.00001337479,0.000005693857,0.00002200039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003589431,0.00008526582,0.0005754606,0.0000216382,0.000006122166,0.00006662876,0.0000246139,0.00002452012,0.9974254,0.00006361278,0.00004511338,0.001302676],"study_design_scores_gemma":[0.00005079143,0.001282462,0.02573309,0.0000115159,0.00002673923,0.0003790293,0.0001352043,0.0003214397,0.969925,0.0001007552,0.002028113,0.000005894244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957139,0.002284967,0.0004260955,0.00008326754,0.00003797171,0.00001322608,0.000156562,0.00001811613,0.001265812],"genre_scores_gemma":[0.9939548,0.002846486,0.0004506546,0.00005956313,0.00002004785,0.00001986764,0.000377838,0.000006850795,0.002263958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304815,"threshold_uncertainty_score":0.004365027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312709950599966,"score_gpt":0.4887746217404077,"score_spread":0.3575036266804111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}