{"id":"W2041806227","doi":"10.1039/c4cc05867d","title":"Chemical modification of temoporfin – a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation","year":2014,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Photosensitizer; Singlet oxygen; Bathochromic shift; Chlorin; Photodynamic therapy; Chemistry; Photochemistry; Phototoxicity; Nanoparticle; Lipophilicity; Nanotechnology; Materials science; Organic chemistry; Oxygen; Fluorescence; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007809912,0.0002304417,0.0001156494,0.0001314873,0.00008249284,0.0001168841,0.0001647326,0.0002457335,0.0009319725],"category_scores_gemma":[0.0001117296,0.0000999835,0.0001333696,0.0000870823,0.000130111,0.0001355808,0.0001276849,0.0002007085,0.0001767888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258627,"about_ca_system_score_gemma":0.00009949312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004515411,"about_ca_topic_score_gemma":0.000498736,"domain_scores_codex":[0.9999415,0.000006644039,0.000002796491,0.00001885459,0.00001383403,0.00001643461],"domain_scores_gemma":[0.9999503,0.00001125864,0.00001560128,0.000005521988,0.000008839339,0.000008530612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001809178,0.000003778265,0.0000247615,0.00001086452,0.00000116011,0.00001262722,0.000004600164,0.00002558272,0.9993694,0.00003170268,0.00001007373,0.0004873097],"study_design_scores_gemma":[0.000002117743,0.00002998818,0.0002893871,7.940641e-7,0.000002719401,0.0000389881,0.000002002701,0.000150911,0.9990277,0.000005102142,0.00044923,0.00000101608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948833,0.0004635911,0.003363392,0.00003591529,0.00001051547,0.00001595273,0.00005046854,0.00004890823,0.001127898],"genre_scores_gemma":[0.9953384,0.0003014212,0.002799007,0.0000234768,0.000003446106,0.00002009581,0.00008112798,0.00001525212,0.001417757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009319725,"threshold_uncertainty_score":0.0031178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1322643987056726,"score_gpt":0.364192141304762,"score_spread":0.2319277425990894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}