{"id":"W2041811734","doi":"10.1016/j.pbiomolbio.2015.02.002","title":"Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal","year":2015,"lang":"en","type":"review","venue":"Progress in Biophysics and Molecular Biology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Hamilton Health Sciences","funders":"Canadian Institutes of Health Research; French Infrastructure for Integrated Structural Biology; Agence Nationale de la Recherche; CNIB","keywords":"DNA mismatch repair; DNA repair; Biology; DNA; Genetics; Computational biology; Mechanism (biology); DNA replication; Gene; Cell biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008335083,0.0003461518,0.00159131,0.0002170486,0.00001349558,0.000007978333,0.00009304218,0.0003573815,3.746991e-7],"category_scores_gemma":[0.0000517773,0.0002473205,0.0001000162,0.0002312252,0.0005274872,0.00001420208,0.000134321,0.0002939151,5.480197e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007276185,"about_ca_system_score_gemma":0.0001166881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002375073,"about_ca_topic_score_gemma":0.00002439491,"domain_scores_codex":[0.9984692,0.0001786013,0.0004817432,0.0005445672,0.0001460075,0.0001798431],"domain_scores_gemma":[0.9992986,0.00010172,0.0002236318,0.0002214291,0.00008183899,0.00007281925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001664278,0.0003082058,0.0003188579,0.004677432,0.0002814831,0.0001370058,0.0007065993,3.587145e-7,0.003182109,0.002524185,0.000002884662,0.9876944],"study_design_scores_gemma":[0.03934174,0.03567863,0.01130086,0.2563897,0.01558227,0.0005496595,0.004343844,0.00100611,0.09227759,0.3016709,0.2311533,0.01070543],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3811933,0.6181588,0.000003649602,0.00002819326,0.00008849158,0.0004720757,0.00003093234,0.000004981631,0.00001960104],"genre_scores_gemma":[0.2648861,0.7341264,0.0006537077,0.00001995217,0.00005771918,0.000105473,0.0001223577,0.00002678185,0.000001441029],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.976989,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05401031171983828,"score_gpt":0.3956505650340023,"score_spread":0.341640253314164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}