{"id":"W2041828209","doi":"10.1210/en.2012-1693","title":"Continuous Administration of a P450 Aromatase Inhibitor Induces Polycystic Ovary Syndrome with a Metabolic and Endocrine Phenotype in Female Rats at Adult Age","year":2012,"lang":"en","type":"article","venue":"Endocrinology","topic":"Ovarian function and disorders","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Novartis Pharma; Novartis","keywords":"Endocrinology; Internal medicine; Polycystic ovary; Letrozole; Anovulation; Aromatase inhibitor; Aromatase; Testosterone (patch); Insulin resistance; Biology; Hyperandrogenism; Ovulation; Endocrine system; Androgen; Estrogen; Medicine; Insulin; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005393548,0.0001804203,0.0004725608,0.0002492576,0.0000373191,0.000006057571,0.00004326922,0.00006509314,0.0001729132],"category_scores_gemma":[0.0001328598,0.0001495802,0.00003414337,0.0002165912,0.0001818686,0.000121082,0.00005130645,0.0001745344,0.00003383814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002434411,"about_ca_system_score_gemma":0.00007168206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001433256,"about_ca_topic_score_gemma":0.0001344709,"domain_scores_codex":[0.9988027,0.00007527469,0.0003171884,0.0002413056,0.0001379772,0.0004255259],"domain_scores_gemma":[0.9993849,0.00007018078,0.0001201257,0.0002264182,0.00004204553,0.0001562871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02062212,0.004413925,0.7087644,0.0008039302,0.0008361221,0.01139385,0.004147333,0.000003773262,0.2161942,0.02086272,0.001492251,0.01046535],"study_design_scores_gemma":[0.008379983,0.001875364,0.9416736,0.0000958441,0.0002610399,0.01087734,0.001207399,0.00000599147,0.03176342,0.00007360921,0.003500956,0.0002854663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952586,0.002068259,0.00001877665,0.0004232745,0.0001782399,0.0003932427,0.00001816231,0.00004814051,0.001593329],"genre_scores_gemma":[0.9985362,0.00009052542,0.0004015454,0.000333094,0.00007241812,0.00004900801,0.00007701608,0.00001998796,0.0004201791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2329091,"threshold_uncertainty_score":0.6099706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553563836468137,"score_gpt":0.2576564407799088,"score_spread":0.2421208024152274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}