{"id":"W2041842685","doi":"10.1016/j.freeradbiomed.2011.07.021","title":"Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells","year":2011,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Society for Redox Biology and Medicine","keywords":"Aryl hydrocarbon receptor; Sulforaphane; Chemistry; NAD+ kinase; Inducer; Messenger RNA; Gene expression; Enzyme inducer; Molecular biology; Reporter gene; Biochemistry; Enzyme; Transcription factor; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251895,0.0002003274,0.0002399809,0.0002315334,0.0002706569,0.0003075023,0.0001126469,0.0001436651,0.002116544],"category_scores_gemma":[0.0001150061,0.0001541882,0.0002897454,0.000243545,0.0002431093,0.0001317728,0.0001758443,0.0003779285,0.0005201552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003378691,"about_ca_system_score_gemma":0.0002117103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004044538,"about_ca_topic_score_gemma":0.00385977,"domain_scores_codex":[0.9998789,0.0000236634,0.000009198141,0.00002926181,0.00002576926,0.00003324083],"domain_scores_gemma":[0.9999098,0.00003228017,0.00001030987,0.00001801308,0.00001383156,0.00001586736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004670398,0.00004148821,0.0005858561,0.00002444117,0.000006311802,0.00005557298,0.00006826095,0.00005001418,0.9975673,0.00009937471,0.0001169437,0.0009175149],"study_design_scores_gemma":[0.00004826156,0.0003154555,0.01451992,0.00000442475,0.00002418412,0.0001500466,0.0001980725,0.0009574037,0.9813544,0.00008074463,0.002337568,0.000009435355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945379,0.000769906,0.00170113,0.0002308262,0.00007017911,0.00001748903,0.0009408522,0.0001214408,0.001610291],"genre_scores_gemma":[0.9924736,0.0003271287,0.0007025978,0.00006319841,0.00001765381,0.00002154233,0.001107238,0.00002174332,0.005265304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004044538,"threshold_uncertainty_score":0.008041978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480416739642866,"score_gpt":0.2493759231526175,"score_spread":0.2345717557561888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}