{"id":"W2041882228","doi":"10.1038/nn1702","title":"Palmitoylation of huntingtin by HIP14is essential for its trafficking and function","year":2006,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":332,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Wellcome Trust","keywords":"Palmitoylation; Huntingtin; Polyglutamine tract; Cell biology; Mutant; Chemistry; Biology; Cysteine; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119743,0.0001481414,0.000128046,0.0001058761,0.0002439722,0.00007918473,0.0002013847,0.00009613564,0.000004240564],"category_scores_gemma":[0.001180563,0.0001435459,0.00005140966,0.0004690727,0.0001778306,0.0002269698,0.00004703727,0.0001709566,8.720231e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008337347,"about_ca_system_score_gemma":0.00003452767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002355465,"about_ca_topic_score_gemma":0.000002368491,"domain_scores_codex":[0.9983652,0.00008218653,0.0002263288,0.0006636712,0.0004019689,0.000260644],"domain_scores_gemma":[0.9992931,0.0002307732,0.000180612,0.0001506706,0.00009007093,0.00005478976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002921265,0.0000630928,0.0007219547,0.00002248504,1.689944e-7,6.502692e-7,0.00001070426,0.0004613445,0.9956236,0.001529689,0.0007041986,0.0008328793],"study_design_scores_gemma":[0.0003081112,0.000123099,0.01483974,0.000007075248,0.00001251296,0.00000444226,0.00000426293,0.005156436,0.9775215,0.0001962776,0.001704325,0.0001222222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945758,0.0002035827,0.003513331,0.0001942329,0.0008224593,0.0003832525,0.00007087262,0.00005558827,0.0001808989],"genre_scores_gemma":[0.998895,0.00001300802,0.000110269,0.0006448395,0.0001172912,0.00001948527,0.000004838545,0.0000167574,0.0001784738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01810212,"threshold_uncertainty_score":0.5853633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102342915954623,"score_gpt":0.2583234966930781,"score_spread":0.2473000675335318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}