{"id":"W2041882228","doi":"10.1038/nn1702","title":"Palmitoylation of huntingtin by HIP14is essential for its trafficking and function","year":2006,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":332,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Wellcome Trust","keywords":"Palmitoylation; Huntingtin; Polyglutamine tract; Cell biology; Mutant; Chemistry; Biology; Cysteine; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004247236,0.000576778,0.0005399437,0.0002591291,0.0006820039,0.0009475707,0.0005843235,0.0007050661,0.001912555],"category_scores_gemma":[0.0005571892,0.0003573801,0.0006110458,0.0002827985,0.0005086964,0.0006617731,0.001320627,0.0007539159,0.001699254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001118497,"about_ca_system_score_gemma":0.0007583715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606549,"about_ca_topic_score_gemma":0.002333648,"domain_scores_codex":[0.9996131,0.00005469398,0.00006648096,0.00007220874,0.0001014919,0.0000920114],"domain_scores_gemma":[0.9994319,0.00004952106,0.0001802807,0.0001054177,0.0001157433,0.0001171446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009757872,0.00004629857,0.001941796,0.0001323641,0.00004954735,0.0006484371,0.00004997235,0.0002756359,0.9877285,0.0009678699,0.0005212073,0.006662612],"study_design_scores_gemma":[0.00004720563,0.00006218356,0.009313473,0.00001882501,0.00003097563,0.0008291687,0.00006690909,0.001689285,0.9812843,0.0003994444,0.006241652,0.00001644211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841167,0.002791584,0.009094649,0.0005082648,0.0002181456,0.00004409842,0.0006249245,0.0002544476,0.002347107],"genre_scores_gemma":[0.9850965,0.0008959419,0.005601253,0.0001848534,0.00002962284,0.00004294301,0.001720732,0.0001443584,0.006283796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912555,"threshold_uncertainty_score":0.008115292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102342915954623,"score_gpt":0.2583234966930781,"score_spread":0.2473000675335318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}