{"id":"W2041892429","doi":"10.1021/bi035122t","title":"Detection of α-Helical Coiled-Coil Dimer Formation by Spin-Labeled Synthetic Peptides:  A Model Parallel Coiled-Coil Peptide and the Antiparallel Coiled Coil Formed by a Replica of the ProP C-Terminus","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Hospital for Sick Children; University of Toronto","funders":"U.S. Public Health Service","keywords":"Coiled coil; Peptide; Antiparallel (mathematics); Chemistry; Heptad repeat; Circular dichroism; Crystallography; Peptide sequence; Protein structure; Site-directed spin labeling; Nuclear magnetic resonance spectroscopy; Stereochemistry; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004843033,0.0004900562,0.0005694338,0.00002279881,0.0002429175,0.00004149311,0.0005712914,0.0005568065,0.00001686396],"category_scores_gemma":[0.0005868127,0.0003466315,0.0003232172,0.0001827065,0.001037723,0.00002236679,0.0002145537,0.000328207,0.000002968949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005208185,"about_ca_system_score_gemma":0.0001910299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003118892,"about_ca_topic_score_gemma":0.000008067879,"domain_scores_codex":[0.9973006,0.0001249418,0.0008953731,0.0007121093,0.0004603548,0.0005066039],"domain_scores_gemma":[0.9975599,0.0000716627,0.0007450464,0.001204726,0.0002492029,0.0001694415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000705058,0.0002714287,0.0001182168,0.0004021404,0.0001295933,0.000001121473,0.0001215411,0.00002777794,0.9895477,0.00001883912,0.008178272,0.0004783247],"study_design_scores_gemma":[0.003785786,0.0001207729,0.0000290718,0.000131838,0.0001921598,0.000165118,0.0002484541,0.003440169,0.9892494,0.0001054411,0.00211805,0.0004137133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928635,0.00218163,0.001124509,0.0002155673,0.00006335272,0.0005227833,0.0001687122,0.00002918534,0.002830765],"genre_scores_gemma":[0.9950235,0.000616795,0.0003267878,0.0001881223,0.00005794853,0.0002003357,0.0001563597,0.00005758864,0.0033725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006060222,"threshold_uncertainty_score":0.9998986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004693642380172075,"score_gpt":0.2093372192979903,"score_spread":0.2046435769178182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}