{"id":"W2041941139","doi":"10.1073/pnas.1213951109","title":"Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ontario Ministry of Economic Development and Innovation; Government of Ontario; Canada Research Chairs; Thalassemia Foundation of Canada; Ottawa Hospital Research Institute","keywords":"Demethylase; Corepressor; Coactivator; Histone methyltransferase; Biology; Histone H3; Histone; Histone H2A; SAP30; Regulation of gene expression; Histone methylation; Genetics; Cell biology; Repressor; Gene expression; Gene; Transcription factor; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002989955,0.00009772139,0.0001429043,0.00003476065,0.0002232455,0.0000104102,0.0005894327,0.00009299861,0.000002922221],"category_scores_gemma":[0.0008115316,0.00004394192,0.0001042093,0.0003323173,0.001482959,0.00003039119,0.0001234602,0.000131276,8.029175e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001004109,"about_ca_system_score_gemma":0.00003238238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004308262,"about_ca_topic_score_gemma":6.177099e-7,"domain_scores_codex":[0.9987267,0.00004703963,0.0003395232,0.0001681381,0.0005667247,0.0001519311],"domain_scores_gemma":[0.9990162,0.0001641295,0.0004760789,0.00002993101,0.0002873641,0.00002629265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004369566,0.00002580867,0.003647485,0.00003383404,0.00002477758,3.575499e-10,0.0002466444,0.00008338796,0.9919174,0.002930819,0.0001536554,0.0008925496],"study_design_scores_gemma":[0.000290856,0.00004211071,0.0158709,0.00002658978,0.00003394753,0.00000202508,0.0003234,0.0002694508,0.9783763,0.004354792,0.0003567192,0.00005290047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934223,0.00315322,0.00007180521,0.002443497,0.00004600266,0.0002344639,0.00002927401,0.000001416608,0.0005979713],"genre_scores_gemma":[0.9988424,0.0004890397,0.0003543069,0.0001378333,0.00007137663,0.00001070923,4.25217e-7,0.000004497242,0.00008947908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01354104,"threshold_uncertainty_score":0.5464025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02820781902887128,"score_gpt":0.2936739817177398,"score_spread":0.2654661626888686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}