{"id":"W2041941139","doi":"10.1073/pnas.1213951109","title":"Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Ontario Ministry of Economic Development and Innovation; Government of Ontario; Canada Research Chairs; Thalassemia Foundation of Canada; Ottawa Hospital Research Institute","keywords":"Demethylase; Corepressor; Coactivator; Histone methyltransferase; Biology; Histone H3; Histone; Histone H2A; SAP30; Regulation of gene expression; Histone methylation; Genetics; Cell biology; Repressor; Gene expression; Gene; Transcription factor; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092815,0.0002371036,0.0001450071,0.0001360244,0.0001422039,0.0002835544,0.0002276501,0.0001765156,0.0005348651],"category_scores_gemma":[0.00008530451,0.0001303923,0.000199669,0.00007522676,0.0002857061,0.0001487979,0.0003869789,0.0002314451,0.0002411829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881731,"about_ca_system_score_gemma":0.0002043389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006532388,"about_ca_topic_score_gemma":0.0009930454,"domain_scores_codex":[0.9999012,0.000009636549,0.000006300198,0.00003856694,0.00002420905,0.00002006281],"domain_scores_gemma":[0.999939,0.000004617033,0.00002568471,0.00001018731,0.000006839789,0.00001382271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003209658,0.00000402502,0.0004393524,0.00001239988,0.000005743108,0.00003259445,0.000009269592,0.00006693012,0.9976441,0.0002397573,0.00002066178,0.001493087],"study_design_scores_gemma":[0.00001109433,0.00008247296,0.009765944,0.000003067321,0.00001701137,0.0002450152,0.00002155379,0.001272642,0.985229,0.0002045639,0.003143633,0.000004152674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865655,0.001480588,0.009552813,0.0001255324,0.00002442843,0.00001654924,0.0001530372,0.0002321521,0.001849386],"genre_scores_gemma":[0.9959385,0.0003258041,0.002110475,0.00003243976,0.000005837984,0.00001017056,0.0001890341,0.00001945538,0.001368304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006532388,"threshold_uncertainty_score":0.002090871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02820781902887128,"score_gpt":0.2936739817177398,"score_spread":0.2654661626888686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}