{"id":"W2041946214","doi":"10.1016/j.molmed.2013.07.002","title":"AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy","year":2013,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Muscular Dystrophy Canada","keywords":"AMPK; Duchenne muscular dystrophy; Skeletal muscle; Protein kinase A; Muscular dystrophy; AMP-activated protein kinase; Context (archaeology); Autophagy; Dystrophin; Biology; Cell biology; Medicine; Endocrinology; Internal medicine; Kinase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002623251,0.0005863117,0.001345102,0.0003281677,0.00005012663,0.000005254886,0.0005289902,0.0005739773,0.0003716959],"category_scores_gemma":[0.0001931868,0.0003806214,0.0003750356,0.0006910265,0.0006291735,0.000004554014,0.000235905,0.0005517791,0.00001419774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000637776,"about_ca_system_score_gemma":0.0001006768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003097135,"about_ca_topic_score_gemma":0.000184531,"domain_scores_codex":[0.9970895,0.000632114,0.0008025009,0.0007221724,0.0002640796,0.0004896486],"domain_scores_gemma":[0.9985535,0.00005688459,0.0004043847,0.0008311556,0.00005862299,0.00009549534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008490318,0.0002742689,0.00000469111,0.001892085,0.0002877413,0.00005016038,0.00008274336,0.00007904064,0.453003,0.0001084969,0.0001983244,0.5439345],"study_design_scores_gemma":[0.00369937,0.001353522,0.0008025659,0.004529902,0.0006521841,0.00003014751,0.00007718868,0.00002399527,0.008314892,0.0002935727,0.9791242,0.001098429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08616355,0.9120308,0.000173827,0.0001101492,0.0001112845,0.000866962,0.0000249728,0.00001084456,0.0005075869],"genre_scores_gemma":[0.2143876,0.7810751,0.0001485972,0.0002527184,0.0002364123,0.0009644472,0.002023262,0.0001720233,0.0007397544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9789259,"threshold_uncertainty_score":0.9998646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855346766574384,"score_gpt":0.3145515424771659,"score_spread":0.2859980748114221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}