{"id":"W2041951873","doi":"10.1096/fj.09-138297","title":"Absence of a catalytic water confers resistance to the neurotoxin gabaculine","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chemistry; Active site; Mutant; Enzyme; Biochemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006075951,0.00008185335,0.0001040833,0.00002824964,0.0002331832,0.00006838054,0.0003757055,0.00002036543,0.0002191411],"category_scores_gemma":[0.00005371188,0.00003299826,0.00004953631,0.00008851682,0.00007098458,0.00008991951,0.00002444078,0.0001640381,0.0001013039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001717323,"about_ca_system_score_gemma":0.0000285337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008191327,"about_ca_topic_score_gemma":0.00002830721,"domain_scores_codex":[0.9991495,0.00008188162,0.0002136402,0.00009986285,0.0002503213,0.0002047987],"domain_scores_gemma":[0.999482,0.00003456886,0.00008447946,0.0002591921,0.00007896905,0.00006073359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009863462,0.000006363206,0.00001467496,0.000002327672,0.000002520139,0.000008056201,0.0007358569,0.0003244885,0.994706,0.0002447547,0.003638524,0.0002177674],"study_design_scores_gemma":[0.0001572637,0.00009702178,0.001536938,0.00002213478,0.00001286282,0.0001290711,0.0001225044,0.00001826178,0.9939492,0.001177134,0.002720134,0.0000574524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887745,0.00006897367,0.001290971,0.007787934,0.0004674599,0.0001443427,0.000007482504,0.00001235746,0.001445956],"genre_scores_gemma":[0.997225,0.00000906795,0.0001529118,0.001423625,0.0002796164,0.000001573957,8.439342e-7,0.000004493316,0.0009028969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008450449,"threshold_uncertainty_score":0.2399442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126345989485166,"score_gpt":0.2340210487220469,"score_spread":0.2213864497735303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}