{"id":"W2041953784","doi":"10.1016/s0303-7207(01)00476-2","title":"Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Medical Research Council Canada","keywords":"Leptin; Biology; Transfection; Promoter; Internal medicine; Reporter gene; Luciferase; Transcription factor; Gene; Endocrinology; Leptin receptor; Repressor; Hormone; Gene expression; Molecular biology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720673,0.0002977171,0.0003170463,0.0005889533,0.0003802041,0.0006500831,0.0002153429,0.0002564234,0.001506806],"category_scores_gemma":[0.0001998758,0.0002383173,0.000527253,0.0003641501,0.0004696299,0.0002677418,0.0003429374,0.0006410739,0.0006389271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007271119,"about_ca_system_score_gemma":0.0004409931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008148845,"about_ca_topic_score_gemma":0.008857438,"domain_scores_codex":[0.9997014,0.00003786355,0.00001840029,0.00005430888,0.00008674264,0.0001012497],"domain_scores_gemma":[0.999806,0.00004688145,0.00003224537,0.00002425245,0.00004251472,0.00004809067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002144505,0.00001586402,0.0002692794,0.00002040446,0.000003633232,0.0000348444,0.00007055146,0.0000337278,0.9982752,0.000273624,0.00004328205,0.0007451116],"study_design_scores_gemma":[0.00005080337,0.0003181537,0.02066947,0.00001806698,0.00002507056,0.000381611,0.0003747894,0.001666842,0.9706158,0.0002492703,0.005611573,0.00001854524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914986,0.00305782,0.002373639,0.0002190526,0.00004021503,0.00001404181,0.0007563384,0.00006321145,0.001977088],"genre_scores_gemma":[0.9892576,0.001012297,0.002276175,0.00009129142,0.00001842468,0.00002402241,0.002400812,0.00004845344,0.004870879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008148845,"threshold_uncertainty_score":0.01620281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229397983962511,"score_gpt":0.2117434755041283,"score_spread":0.1994494956645032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}