{"id":"W2041958591","doi":"10.1182/blood-2013-06-511139","title":"Somatic activating ARAF mutations in Langerhans cell histiocytosis","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Leids Universitair Medisch Centrum; Histiocytosis Association","keywords":"Vemurafenib; Langerhans cell histiocytosis; Cancer research; Somatic cell; Mutation; Exome sequencing; Biology; Exome; Genetics; Medicine; Internal medicine; Melanoma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216149,0.0001704723,0.0001336402,0.0003779181,0.0001663243,0.0001846456,0.00008971192,0.0002924362,0.00102591],"category_scores_gemma":[0.0003942496,0.00009687631,0.00009387444,0.0001685097,0.000199219,0.0001049639,0.0001253222,0.0001809596,0.0002179418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461548,"about_ca_system_score_gemma":0.00008704916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002908422,"about_ca_topic_score_gemma":0.0004519689,"domain_scores_codex":[0.9999264,0.00001108014,0.000007567757,0.0000195605,0.00001880677,0.00001658097],"domain_scores_gemma":[0.9999193,0.00003433579,0.00001498798,0.000008992803,0.000008972679,0.00001343378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009336952,0.0001888305,0.1915975,0.0001108986,0.00006613103,0.06995257,0.000365592,0.0005256588,0.6838009,0.0005363425,0.0006078795,0.05131397],"study_design_scores_gemma":[0.0001420013,0.0009797475,0.3530305,0.00004411169,0.000173284,0.2903496,0.0003111032,0.002460303,0.342674,0.0009311786,0.008872245,0.00003180447],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976287,0.0003952177,0.0005804569,0.00003778735,0.000005200513,0.0000130443,0.00007539441,0.00002044803,0.001243669],"genre_scores_gemma":[0.9992288,0.0001054472,0.0004159559,0.00001997181,0.000003639975,0.000002502932,0.00004880666,0.000004109504,0.0001707141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102591,"threshold_uncertainty_score":0.003432035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009873138923125727,"score_gpt":0.2357646111329434,"score_spread":0.2258914722098177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}