{"id":"W2041976760","doi":"10.1371/journal.pone.0013040","title":"USP7/HAUSP Promotes the Sequence-Specific DNA Binding Activity of p53","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"National Cancer Institute","keywords":"Cell biology; Biology; Transcription factor; DNA; Gene; Ubiquitin; Plasma protein binding; DNA-binding domain; DNA-binding protein; Suppressor; Transcription (linguistics); In vitro; Regulation of gene expression; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598859,0.0001339754,0.0002888263,0.00008586357,0.00007775175,0.00001444893,0.0001491914,0.0001361927,0.0003131762],"category_scores_gemma":[0.00024044,0.00009864174,0.00008451255,0.0002835362,0.000184596,0.00006322443,0.00005661085,0.0006480453,0.00008892696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006265725,"about_ca_system_score_gemma":0.0001243173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003315161,"about_ca_topic_score_gemma":0.00004407289,"domain_scores_codex":[0.9988174,0.00003706335,0.0001814982,0.0002433874,0.0004806339,0.0002399671],"domain_scores_gemma":[0.9989306,0.00008389024,0.0001289187,0.0006403133,0.0001226904,0.0000935772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007066286,0.00070549,0.0008094006,0.00009233623,0.0001651375,0.00001977412,0.0002764705,2.608485e-7,0.9951431,0.0001871034,0.000115948,0.002414343],"study_design_scores_gemma":[0.0005785095,0.0001932407,0.003032134,0.0002731494,0.0001672455,0.00002281311,0.00002524202,0.0001294229,0.9946972,0.00007713591,0.0007003201,0.0001035793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945261,0.0001056315,0.00002636032,0.001431082,0.0001331332,0.0006364446,0.00002290463,0.00007538312,0.003042957],"genre_scores_gemma":[0.9980462,0.00007257711,0.00112704,0.00004777356,0.0002011085,0.0000331766,0.000009981946,0.00003384981,0.0004283563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003520031,"threshold_uncertainty_score":0.4022493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08547812366886831,"score_gpt":0.261995981637159,"score_spread":0.1765178579682907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}