{"id":"W2042001439","doi":"10.1210/endo.142.6.8195","title":"Thiol-Reactive Agents Biphasically Regulate Inositol 1,4,5-Trisphosphate Binding and Ca2+ Release Activities in Bovine Adrenal Cortex Microsomes*","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Dithiothreitol; Inositol; Receptor; Thiol; Ryanodine receptor; Intracellular; Chemistry; Microsome; Biochemistry; Western blot; Internal medicine; Endocrinology; Biology; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816436,0.0003886957,0.0002683203,0.000140292,0.0001118077,0.0002447841,0.0001757104,0.0001851899,0.0007768539],"category_scores_gemma":[0.0002026651,0.000127077,0.0002145054,0.0001346916,0.0002361151,0.0002054644,0.0001268146,0.0002854782,0.0002963948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003956151,"about_ca_system_score_gemma":0.0001701751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001333747,"about_ca_topic_score_gemma":0.002243536,"domain_scores_codex":[0.9998709,0.00001915474,0.00001068005,0.00003227571,0.00003366503,0.00003336586],"domain_scores_gemma":[0.9998732,0.00002930147,0.00003215468,0.00001779028,0.00001923658,0.00002839866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406381,0.000005963597,0.00007702994,0.00001582774,0.000002258601,0.000016956,0.000009440016,0.00001027277,0.9993098,0.00001500447,0.000009217777,0.0003875502],"study_design_scores_gemma":[0.00001333097,0.0002131698,0.006893571,0.000002353796,0.00001602486,0.0001248142,0.00002083842,0.000328297,0.991402,0.00002214924,0.0009575518,0.000005906511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907925,0.005025909,0.002599061,0.00009716768,0.00003762273,0.00002777912,0.0003274219,0.00009390631,0.0009986532],"genre_scores_gemma":[0.9952103,0.001082849,0.001464301,0.0000490482,0.00001497213,0.00002175374,0.0004538614,0.00002180307,0.001681083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333747,"threshold_uncertainty_score":0.002870381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026503453615678,"score_gpt":0.2556619756455628,"score_spread":0.245396941109406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}