{"id":"W2042001439","doi":"10.1210/endo.142.6.8195","title":"Thiol-Reactive Agents Biphasically Regulate Inositol 1,4,5-Trisphosphate Binding and Ca2+ Release Activities in Bovine Adrenal Cortex Microsomes*","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Dithiothreitol; Inositol; Receptor; Thiol; Ryanodine receptor; Intracellular; Chemistry; Microsome; Biochemistry; Western blot; Internal medicine; Endocrinology; Biology; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007882923,0.0002394159,0.0002657599,0.0001749371,0.0001143798,0.00002884852,0.0001330589,0.0001693726,0.00005177503],"category_scores_gemma":[0.00007121245,0.0002441043,0.00007002583,0.0001600651,0.0001753635,0.0000132131,0.000169185,0.0002062583,0.000007790928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004408262,"about_ca_system_score_gemma":0.00006915037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001179299,"about_ca_topic_score_gemma":0.000105509,"domain_scores_codex":[0.9984636,0.0001127144,0.0002836915,0.0005106256,0.0001082294,0.0005210998],"domain_scores_gemma":[0.999431,0.00002629166,0.0001325038,0.0002531642,0.00003965984,0.0001173543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006056709,0.0001068088,0.0259491,0.00001641498,0.00006716525,0.0003599754,0.00008567045,0.00002261676,0.9633204,0.0002660932,0.0003143557,0.008885737],"study_design_scores_gemma":[0.002902827,0.0003833951,0.06701015,0.00005959159,0.00003066073,0.0006213071,0.0001598589,0.0001822068,0.8925992,0.0001942773,0.03538531,0.0004712112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969465,0.001494502,0.0001658204,0.0006203026,0.0001239734,0.000272382,0.00002860123,0.00003000193,0.0003179068],"genre_scores_gemma":[0.9973972,0.0008374103,0.0002881647,0.0004427107,0.0001194365,0.00003937115,0.0001260041,0.00002770614,0.0007220239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0707212,"threshold_uncertainty_score":0.9954286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026503453615678,"score_gpt":0.2556619756455628,"score_spread":0.245396941109406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}