{"id":"W2042011503","doi":"10.1089/hyb.2008.0011","title":"A Novel Approach to Development of Monoclonal Antibodies Using Native Antigen for Immunization and Recombinant Antigen for Screening","year":2008,"lang":"en","type":"article","venue":"Hybridoma","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Defence Research and Development Canada","funders":"Defence Research and Development Canada","keywords":"Immunogen; Monoclonal antibody; Antigen; Bacillus anthracis; Recombinant DNA; Biology; Hybridoma technology; Antibody; Microbiology; Molecular biology; Virology; Immunoassay; Gene; Immunology; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385639,0.0001149142,0.0001820178,0.0000625687,0.0002578777,0.00001301729,0.0001002523,0.00005798668,8.925506e-7],"category_scores_gemma":[0.0001058609,0.000109594,0.00005061163,0.00007435729,0.00006726886,0.000006055031,0.0001030499,0.00002647781,1.609726e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001032782,"about_ca_system_score_gemma":0.000118247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002785328,"about_ca_topic_score_gemma":0.0000044544,"domain_scores_codex":[0.999184,0.0000138979,0.0002188712,0.0002635356,0.00009529144,0.0002244159],"domain_scores_gemma":[0.9994621,0.00001903188,0.00007484692,0.000117537,0.0002677887,0.00005866031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003790396,0.00008323184,0.001993255,0.00005128057,0.00007198855,2.211708e-7,0.0004663786,0.00005917478,0.9913812,0.00004391181,0.00008087412,0.005389491],"study_design_scores_gemma":[0.001605204,0.000279346,0.02899623,0.00003986161,0.000008613325,0.00003540321,0.0001569144,0.005573558,0.954678,0.00002438142,0.008347629,0.000254887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.610405,0.0001777187,0.3888733,0.000007765249,0.00003730156,0.0004114235,0.00004246444,0.000002451294,0.00004260039],"genre_scores_gemma":[0.7187141,0.00008328518,0.2808476,0.00001541892,0.00005507376,0.00003292276,0.0001718187,0.00001694555,0.00006285612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1083091,"threshold_uncertainty_score":0.4469113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08387090776602231,"score_gpt":0.3070105102903535,"score_spread":0.2231396025243312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}