{"id":"W2042011503","doi":"10.1089/hyb.2008.0011","title":"A Novel Approach to Development of Monoclonal Antibodies Using Native Antigen for Immunization and Recombinant Antigen for Screening","year":2008,"lang":"en","type":"article","venue":"Hybridoma","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Defence Research and Development Canada","funders":"Defence Research and Development Canada","keywords":"Immunogen; Monoclonal antibody; Antigen; Bacillus anthracis; Recombinant DNA; Biology; Hybridoma technology; Antibody; Microbiology; Molecular biology; Virology; Immunoassay; Gene; Immunology; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004345039,0.0007279786,0.0005805616,0.0006170056,0.0002325895,0.0003887476,0.0005703578,0.0007373759,0.0007170755],"category_scores_gemma":[0.0002746905,0.0003481694,0.0005198598,0.0003040272,0.0003344877,0.0004062603,0.0004707113,0.001302069,0.0004644726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934436,"about_ca_system_score_gemma":0.0002705666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002359142,"about_ca_topic_score_gemma":0.0003383794,"domain_scores_codex":[0.9996182,0.00007373955,0.00003087086,0.0001059058,0.0001285725,0.00004268291],"domain_scores_gemma":[0.999849,0.00003134645,0.00003004026,0.00002712008,0.00003812468,0.00002433802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001977701,0.0000494104,0.00009102953,0.00005600544,0.0000101594,0.0000509932,0.00001396141,0.00005134092,0.9941857,0.0002719981,0.00004867281,0.005150875],"study_design_scores_gemma":[0.00005150601,0.001047129,0.001305838,0.00001233512,0.00007247023,0.00170843,0.00001452145,0.001873867,0.9818671,0.0003210676,0.01170489,0.00002079724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4176529,0.006920365,0.5682893,0.000671984,0.0004280422,0.0005438131,0.0003040251,0.0009954084,0.004194122],"genre_scores_gemma":[0.5835062,0.006128056,0.4014848,0.0006067614,0.0001634222,0.0005445427,0.000946517,0.00007126822,0.006548553],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0007373759,"threshold_uncertainty_score":0.002398849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08387090776602231,"score_gpt":0.3070105102903535,"score_spread":0.2231396025243312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}