{"id":"W2042035007","doi":"10.1016/j.biocel.2009.10.020","title":"Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferase","year":2009,"lang":"en","type":"article","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Phosphoribosyltransferase; Hypoxanthine-guanine phosphoribosyltransferase; Xanthine; Hypoxanthine; Biochemistry; Adenine phosphoribosyltransferase; Hypoxanthine Phosphoribosyltransferase; Purine; Guanine; Xanthine dehydrogenase; Chemistry; Biology; Enzyme; Mutant; Xanthine oxidase; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636958,0.0002343918,0.0002315983,0.0001312444,0.0001770307,0.0003449102,0.0002233077,0.0003336832,0.0009642692],"category_scores_gemma":[0.0002893785,0.000240959,0.0001348074,0.00009110248,0.0004357292,0.0002571716,0.0002515671,0.0003511278,0.0005458372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612322,"about_ca_system_score_gemma":0.0001230326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001865661,"about_ca_topic_score_gemma":0.0005198449,"domain_scores_codex":[0.9998865,0.00003561646,0.000008391345,0.00001886005,0.0000200808,0.0000306134],"domain_scores_gemma":[0.9997702,0.00007620007,0.00005957773,0.00002321795,0.00002250735,0.00004828757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001998658,0.00001269109,0.0006694762,0.00002445044,0.00000463062,0.0001299577,0.0000265893,0.0001259703,0.9973674,0.0002849679,0.00001633782,0.001137609],"study_design_scores_gemma":[0.00003718833,0.0002173445,0.01565636,0.000008383992,0.00002558972,0.001208672,0.00007927466,0.001880859,0.9792385,0.0003369607,0.001295609,0.00001522153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979652,0.0002808839,0.001036761,0.00002901569,0.000003574723,0.000004798764,0.00002172591,0.00001792176,0.0006401889],"genre_scores_gemma":[0.9992119,0.00008369804,0.0003472613,0.00001656593,0.000002506602,0.000002552654,0.00005065584,0.000007301718,0.0002775284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009642692,"threshold_uncertainty_score":0.003225863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873468575408199,"score_gpt":0.2573500219781014,"score_spread":0.2486153362240194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}