{"id":"W2042035007","doi":"10.1016/j.biocel.2009.10.020","title":"Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferase","year":2009,"lang":"en","type":"article","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Phosphoribosyltransferase; Hypoxanthine-guanine phosphoribosyltransferase; Xanthine; Hypoxanthine; Biochemistry; Adenine phosphoribosyltransferase; Hypoxanthine Phosphoribosyltransferase; Purine; Guanine; Xanthine dehydrogenase; Chemistry; Biology; Enzyme; Mutant; Xanthine oxidase; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001002892,0.0001977937,0.0002023302,0.00003492838,0.00009983413,0.00003981174,0.002364131,0.0001706435,0.0000445788],"category_scores_gemma":[0.0002230841,0.00008884201,0.0002789586,0.0001903888,0.0005021028,0.000006343985,0.0002504451,0.0005951818,0.000003809921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004599152,"about_ca_system_score_gemma":0.0001330761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009117541,"about_ca_topic_score_gemma":0.00003688549,"domain_scores_codex":[0.9983014,0.0001793627,0.0005461094,0.0002374983,0.0004650202,0.0002705535],"domain_scores_gemma":[0.9987317,0.00009586847,0.0003429689,0.0005052447,0.0002766133,0.00004757266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004608076,0.0001799674,0.001364674,0.000008282489,0.0000734862,0.00001628396,0.0000677643,0.00001432937,0.9946689,0.00009539041,0.002105777,0.0009443586],"study_design_scores_gemma":[0.0006436854,0.0002198231,0.001985496,0.0000330622,0.00002381643,0.0001908602,0.0001696032,0.000006639647,0.9836885,0.0002725507,0.01266252,0.0001034785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982243,0.002702095,0.00005835209,0.01353718,0.0002174192,0.0001505551,0.0000710272,0.000002310177,0.001018079],"genre_scores_gemma":[0.9965967,0.001493671,0.00004119065,0.0009208719,0.0005954693,0.000003254663,0.00005621176,0.000009956547,0.0002826903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0143537,"threshold_uncertainty_score":0.4393183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873468575408199,"score_gpt":0.2573500219781014,"score_spread":0.2486153362240194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}