{"id":"W2042041233","doi":"10.1073/pnas.0911844107","title":"Competition between native topology and nonnative interactions in simple and complex folding kinetics of natural and designed proteins","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Folding (DSP implementation); Protein folding; Cooperativity; Contact order; Kinetics; Crystallography; Sequence (biology); Topology (electrical circuits); Native state; Downhill folding; Chemistry; Phi value analysis; Protein structure; Chemical physics; Biophysics; Biological system; Biology; Physics; Biochemistry; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257428,0.0003245782,0.000319811,0.0001326874,0.0001678133,0.0003504426,0.0003559529,0.0003352648,0.0003766341],"category_scores_gemma":[0.0005204538,0.000146918,0.000343759,0.0001222006,0.0003487229,0.0003583208,0.0001654242,0.0003300533,0.00008146205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006499874,"about_ca_system_score_gemma":0.0002735341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001716848,"about_ca_topic_score_gemma":0.001042168,"domain_scores_codex":[0.9998829,0.0000211147,0.000008868034,0.00003217738,0.00002696049,0.00002798036],"domain_scores_gemma":[0.9998308,0.00006264511,0.00003461661,0.00002248576,0.00001962279,0.00002974941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003448555,0.0001132267,0.005591318,0.0001334025,0.00007113421,0.000277965,0.0001421005,0.2313527,0.7576006,0.00213245,0.00007256994,0.002167681],"study_design_scores_gemma":[0.00002557382,0.0002996516,0.003762646,0.000004930853,0.00003100701,0.0000889374,0.00006359058,0.7382747,0.2563,0.0006816203,0.0004389583,0.00002829266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963517,0.00003832429,0.003382104,0.0000109336,0.000002563061,0.000004304659,0.00003481184,0.00002611071,0.0001490182],"genre_scores_gemma":[0.9977618,0.00004995461,0.001973846,0.000005448469,8.450475e-7,0.0000109236,0.00007040807,0.00001029864,0.0001164243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001716848,"threshold_uncertainty_score":0.004716039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573955363636636,"score_gpt":0.3200755221792274,"score_spread":0.294335968542861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}