{"id":"W2042046941","doi":"10.1074/jbc.m109.063263","title":"Substrate Binding and Active Site Residues in RNases E and G","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Active site; Binding site; Substrate (aquarium); Chemistry; Substrate specificity; Biochemistry; Stereochemistry; Biology; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003443987,0.00048318,0.0003446637,0.0001823577,0.0002222642,0.0005426751,0.0003781992,0.0009230825,0.0005615018],"category_scores_gemma":[0.0006997688,0.0002638524,0.0003660702,0.0001703384,0.0004970604,0.0003981522,0.0001945922,0.0006103639,0.0004492598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004279689,"about_ca_system_score_gemma":0.0003018861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007243963,"about_ca_topic_score_gemma":0.0006927321,"domain_scores_codex":[0.9996186,0.0001185529,0.00003034225,0.0000938079,0.00007993676,0.00005858832],"domain_scores_gemma":[0.9995784,0.0001742818,0.0001011346,0.00004748768,0.00003223416,0.00006636324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000633836,0.00005334271,0.002208935,0.00006454031,0.00001313316,0.0002971239,0.00003596017,0.001325941,0.9906896,0.000750678,0.00006199895,0.003864909],"study_design_scores_gemma":[0.00005239035,0.0005272641,0.009209542,0.00001182855,0.000027626,0.0009953411,0.00006683914,0.004350605,0.9818323,0.0007980895,0.002102705,0.00002543784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931483,0.001246451,0.004886675,0.0001122254,0.00002027099,0.000009491993,0.0001059255,0.00005983657,0.0004107755],"genre_scores_gemma":[0.9963942,0.0002675914,0.002704056,0.00006914601,0.00000600573,0.000007036305,0.0002122136,0.00001540592,0.0003242294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009230825,"threshold_uncertainty_score":0.003105223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182693494181256,"score_gpt":0.2528794577879956,"score_spread":0.23461010836987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}