{"id":"W2042108686","doi":"10.1111/j.1460-9568.2006.04873.x","title":"The<i>Drosophila cac</i><sup><i>ts2</i></sup>mutation reduces presynaptic Ca<sup>2+</sup>entry and defines an important element in Ca<sub>v</sub>2.1 channel inactivation","year":2006,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Neurotransmission; Mutant; Patch clamp; Mutation; Cell biology; Biophysics; Biology; Voltage-dependent calcium channel; Ion channel; Neurotransmitter; Chemistry; Neuroscience; Electrophysiology; Biochemistry; Calcium; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026011,0.0001980133,0.0001490425,0.0001417056,0.0003007138,0.0001463192,0.0002461128,0.0000454747,0.0000013638],"category_scores_gemma":[0.0002496681,0.000158437,0.0000643636,0.0002578955,0.0001831172,0.00008310178,0.00007495186,0.0001835245,0.000002274817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003537063,"about_ca_system_score_gemma":0.00008346745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000092815,"about_ca_topic_score_gemma":0.00000686078,"domain_scores_codex":[0.9979079,0.0003888767,0.0006733907,0.0003688323,0.0003616252,0.0002994022],"domain_scores_gemma":[0.998999,0.00002765181,0.0004658497,0.0002001322,0.0001867383,0.0001206465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002065997,0.0001292389,0.0005250374,0.00001034676,0.000005545168,0.00008186579,0.0002514731,0.09061447,0.9052695,0.0000636344,0.0006460282,0.002196255],"study_design_scores_gemma":[0.004579535,0.005248895,0.212248,0.0002056481,0.00008188142,0.002502627,0.002354298,0.3072051,0.4444418,0.0007340072,0.01922641,0.001171853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975387,0.000336251,0.0006628573,0.0007482763,0.0003369765,0.0001694845,0.000007787903,0.000008699111,0.0001910112],"genre_scores_gemma":[0.9982681,0.0005956665,0.00005196648,0.0003403153,0.0006103526,0.000003874819,0.00002552881,0.00002600724,0.00007814165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4608277,"threshold_uncertainty_score":0.6460875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197250954275435,"score_gpt":0.2240525630079412,"score_spread":0.2120800534651869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}